891830-59-4Relevant academic research and scientific papers
Iron-catalyzed C-H bond functionalization for the exclusive synthesis of pyrido[1,2-a]indoles or triarylmethanols
Karthikeyan, Iyyanar,Sekar, Govindasamy
, p. 8055 - 8063 (2014)
The efficient and selective iron-catalyzed C-H activation of 2-benzhydrylpyridine derivatives was employed for the preparation of pyrido[1,2-a]indoles through an intramolecular C-H amination reaction. In the presence of molecular oxygen as the sole oxidant, the same 2-benzhydrylpyridines were also used for the synthesis of the corresponding tertiary alcohols. In these approaches, the iron catalyst was used to selectively activate the C(sp2)-H bond of 2-benzhydrylpyridine, in the case of the intramolecular ring-closing C-H amination reaction in which the pyridine nitrogen atom was a directing group as well as a nucleophile, and the C(sp3)-H bond of the same compound, in the case of the oxidation reaction to give the corresponding triaryl carbinol.
An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization
Karthikeyan, Iyyanar,Arunprasath, Dhanarajan,Sekar, Govindasamy
supporting information, p. 1701 - 1704 (2015/03/03)
Transition metal free Br?nsted acid mediated synthesis of biologically important pyrido[1,2-a]indole scaffolds through aza-Nazarov type cyclization of readily available diaryl(2-pyridyl)methanol using formic acid has been developed. This methodology has b
Azaphilic versus Carbophilic Coupling at C=N Bonds: Key Steps in Titanium-Assisted Multicomponent Reactions
Roth, Torsten,Wadepohl, Hubert,Clot, Eric,Gade, Lutz H.
supporting information, p. 18730 - 18738 (2016/01/25)
Consecutive C- and N-arylation of N-heterocyclic nitriles is mediated by titanium(IV) alkoxides. The carbo- and azaphilic arylation step may be separated by choosing the order in which the two equivalents of aryl transfer reagent are added. In the course of this transformation, the ancillary N-heterocycle acts as both a directing anchor group and electron reservoir. In the selectivity-determining step, the selectivity is governed by a choice between (direct) C- and Ti-arylation; the latter opens up a reaction pathway that allows further migration to the nitrogen atom. The isolation of metal-containing aggregates from the reaction mixture and computational studies gave insights into the reaction mechanism. Subsequently, a multicomponent one-pot protocol was devised to rapidly access complex quaternary carbon centers.
Oxovanadium(IV) complexes as molecular catalysts in epoxidation: Simple access to pyridylalkoxide derivatives
Lobmaier, Gerhard M.,Trauthwein, Harald,Frey, Guido D.,Scharbert, Bernd,Herdtweck, Eberhardt,Herrmann, Wolfgang A.
, p. 2291 - 2296 (2007/10/03)
Reaction of bis(aryl)-2-pyridylmethanol ligands (1a-7a) with VO(SO4) · 5H2O results in the formation of metal-oxo complexes [VO(N-O)2] (1-7), with N-O = bis(aryl)-2-pyridylmethanol. A molecular structure of (4) has been de
