891845-32-2Relevant academic research and scientific papers
Discovery of novel and long acting muscarinic acetylcholine receptor antagonists
Jin, Jian,Wang, Yonghui,Shi, Dongchuan,Wang, Feng,Davis, Roderick S.,Jin, Qi,Fu, Wei,Foley, James J.,Webb, Edward F.,Dehaas, Chris J.,Berlanga, Manuela,Burman, Miriam,Sarau, Henry M.,Morrow, Dwight M.,Rao, Parvathi,Kallal, Lorena A.,Moore, Michael L.,Rivero, Ralph A.,Palovich, Michael,Salmon, Michael,Belmonte, Kristen E.,Busch-Petersen, Jakob
supporting information; experimental part, p. 4866 - 4869 (2009/08/09)
High throughput screening and subsequent optimization led to the discovery of novel quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excellent selectivity. Compounds 8a, 13a, and 13b showed excellent inhibitory
Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas
Jin, Jian,Wang, Yonghui,Shi, Dongchuan,Wang, Feng,Fu, Wei,Davis, Roderick S.,Jin, Qi,Foley, James J.,Sarau, Henry M.,Morrow, Dwight M.,Moore, Michael L.,Rivero, Ralph A.,Palovich, Michael,Salmon, Michael,Belmonte, Kristen E.,Busch-Petersen, Jakob
scheme or table, p. 5481 - 5486 (2009/06/18)
SAR exploration of multiple regions of a tyrosine urea template led to the identification of very potent muscarinic acetylcholine receptor antagonists such as 10b with good subtype selectivity for M3 over M1. The structure-activity r
NOVEL M3 MUSCARINIC ACETYCHOLINE RECEPTOR ANTAGONISTS
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Page/Page column 55-56, (2008/06/13)
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
QUATERNARY AMMONIUM SALTS OF FUSED HETEAROMATIC AMINES AS NOVEL MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
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Page/Page column 15, (2010/11/08)
Novel derivatives of cyclic amines, pharmaceutical compositions, processes for their preparation, and use thereof in treating muscarinic acetylcholine receptor mediated diseases are provided.
