891863-20-0Relevant academic research and scientific papers
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors
Andrews, David M.,Stokes, Elaine S.E.,Carr, Greg R.,Matusiak, Zbigniew S.,Roberts, Craig A.,Waring, Michael J.,Brady, Madeleine C.,Chresta, Christine M.,East, Simon J.
, p. 2580 - 2584 (2008/12/21)
A lead benzamide, 3, was identified as a potent and low molecular weight histone deacetylase (HDAC) inhibitor. Optimization led to 16d, demonstrating an excellent balance of efficacy and non-efficacy properties, along with very desirable in vivo DMPK. The
N- (2-AMINOPHENYL) -4- (5- ((ETHYLAMINO) METHYL) 1,3-THIAZOL-2-YL) BENZAMIDE AND N- (2-AMINOPHEYNL) -4- (5- ((ISOPROPYLAMINO) METHYL) -1,3-THIAZOL-2-YL) BENZAMIDE AS HDAC INHIBITORS
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Page/Page column 36-37, (2008/06/13)
The invention concerns novel benzamide compounds of Formula ( I ): wherein R wherein is ethyl or isopropyl; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharma
