95453-58-0

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE serves as a crucial intermediate in the production of various pharmaceuticals. Its role in this industry is pivotal for the synthesis of drugs that target a wide array of health conditions, capitalizing on its ability to form complex molecular structures.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE is employed as an intermediate for the development of compounds that contribute to crop protection and enhancement of agricultural yields. Its integration into these products is essential for creating effective solutions against pests and diseases.
Used in Dye Industry:
2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE also finds application in the dye industry, where it is used as an intermediate to produce a variety of dyes. Its chemical properties allow for the creation of dyes with specific colorfastness and stability properties, meeting the demands of different applications.
Used as a Building Block in Synthesis:
Beyond its role as an intermediate, 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE is also utilized as a building block in the synthesis of various heterocyclic compounds. Its structural attributes make it a valuable component in the creation of complex organic molecules for diverse applications across different industries.

InChI:InChI=1/C4H2ClNOS/c5-4-6-1-3(2-7)8-4/h1-2H

Upstream product

• 3034-52-4 2-chlorothiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 1011-41-2 2-(morpholin-4-yl)thiazole-5-carbaldehyde 
• 101012-12-8 2-chloro-1,3-thiazole-5-carboxylic acid 
• 1263089-44-6 N-[(2-chloro-5-thiazolyl)methyl]-3-phenyl-2-pyridinamine 
• 1263089-43-5 N-[(2-chloro-5-thiazolyl)methylene]-3-phenyl-2-pyridinamine 
• 891863-20-0 tert-butyl (2-{[4-(5-formyl-1,3-thiazol-2-yl)benzoyl]amino}phenyl)carbamate 
• 145015-15-2 2-chloro-5-(hydroxymethyl)thiazole 

Relevant academic research and scientific papers

SUBSTITUTED PYRIMIDINIUM COMPOUNDS FOR COMBATING ANIMAL PESTS

Substituted pyrimidinium compounds of the general formula (I), wherein X, Y, Z, R1, R2, A and Het are defined as in the description, are useful for controlling invertebrate pests.

Dehydroamino acids

Compounds of formula 1 and 1-1, wherein R1 is hydrogen, hydroxy, amino or halogen, R2 is hydrogen, hydroxy, or halogen and R3 is hydrogen (Formula 1) or R1 is hydrogen and R2 and R3 taken together with the ethenylene group connecting them form phenyl, pyrrole, pyrroline, oxopyrroline, pyrazole, triazole, or imidazole (Formula 1-1), A is R4 R5 are hydrogen, methyl, ethyl or halogen except that R4 r5 cannot both be hydrogen; and 1) B is hydrogen, or lower alkyl; or 2) B is where R6 R7 R8 and R9 are independently hydrogen, hydroxy, aminosulfonyl, halogen, lower alkoxy, cyano, amino, lower alkyl, lower alkyl amino, or nitro; or 3) B is where R10 is hydrogen, hydroxy, halogen, or lower alkyl and C is a five- or six- membered ring with 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur, which ring may be unsubstituted or mono- or di- substituted with lower alkyl, cycloalkyl, amino, or substituted amino; 4) B is where X and Y are independently methylene or nitrogen; or 5) B is where at leat one of T, U, V, or W is nitrogen, and any of T, U, V or W which is carbon may be substituted with lower alkyl, lower alkyl amino, lower alkoxy, hydroxy, aminosulfonyl, halogen, cyano, amino, or nitro; or 6) B is where Y is carbon or nitrogen; or 7) B is a five-membered aromatic ring with 1 to 3 heteratoms selected from nitrogen, oxygen, and sulfur which ring may be unsubstituted or mono- or di-substituted with lower alkyl, cycloalky, trifluoroloweralkyl, amino, halogen, substituted amino, or which ring may be fused with a 5 or 6 membered aromatic ring containing 0 to 3 heteroatoms which heteroatoms are selected from nitrogen, oxygen, and sulfur; and pharmaceutically acceptable salts thereof, and related prodrugs, pharmaceutical compositions and methods of treatment, which compounds are useful for treating psoriasis.

An Easy General Synthesis of 2-(N,N-Dialkylamino)thiazol-5-yl Aldehydes and Ketones

Reaction between 2-chloro-5-thiazolyl-lithium and N,N-dialkylformamides or amides gave 2-N,N-dialkylaminothiazol-5-yl aldehydes or ketones on quenching with water.Quenching with acid gave 2-chlorothiazole-5-yl aldehydes or ketones, from which chloride was easily displaced by free amines.