89192-94-9Relevant academic research and scientific papers
I2-mediated and direct synthesis of 3-phenoxy imidazo heterocycles
Guo, Yanchun,Wang, Yuexiu,Xue, Han,Cao, Shuxia,Zhao, Yufen
, p. 1481 - 1491 (2019)
An I2-mediated protocol was proposed for the synthesis of 3-phenoxy imidazo heterocycles from aromatic ketones and 2-aminopyridines or 2-aminobenzothiazole. This direct, efficient and operationally simple method provided a fundamentally novel a
Copper-Catalyzed Oxidative Cyclization of 2-Amino-azaarenes with Lignin Models: Synthesis of 3-Phenoxy Imidazo Heterocycles
Zhang, Jian,Lu, Xiunan,Li, Tingyan,Wang, Shanlu,Zhong, Guofu
, p. 5222 - 5229 (2017)
A catalytic oxidative cyclization of 2-aminopyridines or 2-aminobenzothiazole with 2-phenoxyacetophenones (a kind of lignin platform compound) was developed, efficiently providing valuable 3-phenoxy imidazo[1,2-a]pyridines or 3-phenoxy benzo[d]imidazo[2,1-b]thiazoles. The reaction was realized under oxygen by simply using inexpensive CuI as the catalyst.
Visible Light Organic Photoredox-Catalyzed C-H Alkoxylation of Imidazopyridine with Alcohol
Kibriya, Golam,Samanta, Sadhanendu,Jana, Sourav,Mondal, Susmita,Hajra, Alakananda
, p. 13722 - 13727 (2017)
The visible light-mediated C-3 alkoxylation of imidazopyridines with alcohols has been achieved using rose bengal as an organic photoredox catalyst at room temperature. Widely abundant air acts as the terminal oxidant that avoids the use of a stoichiometric amount of peroxo compounds. A wide range of functional groups could be tolerated under the reaction conditions to produce C(sp2)-H alkoxylated products in high yields.
Method for preparing C-3 oxo substituted imidazole heterocyclic compounds
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Paragraph 0082-0084, (2017/08/31)
The invention relates to a method for synthesizing a compound represented by a formula (1) or a formula (2) or a formula (3) shown in the description. The method specifically comprises the steps of putting an o-amino nitrogen heterocyclic compound, a 2-oxo acetophenone derivative and a transition-metal salt catalyst into an organic solvent, carrying out a heated reaction in an oxygen-containing atmosphere, and subjecting the reaction solution to aftertreatment after the reaction ends, thereby obtaining the compound represented by the formula (1) or formula (2) or formula (3). 2-amino heterocyclic compounds are 2-aminopyridine compounds or 2-aminobenzo[d]thiazole compounds or 1-amino isoquinoline. According to the method disclosed by the invention, the operation is simple, the reaction conditions are mild, the byproduct is restricted to water, the reaction yield is high and reaches 97% to the maximum, and two kinds of heterocyclic compounds synthesized have pharmacological properties and can serve as important precursors of medicines.
