89237-07-0Relevant academic research and scientific papers
Direct 4-Alkylation of 1,3-Cyclohexanediones via Dianionic Species
Berry, Nicola M.,Darey, Mark C. P.,Harwood, Laurence M.
, p. 476 - 480 (2007/10/02)
1,3-Cyclohexanediones are directly alkylated at the 4 position via dianionic species generated at -78 deg C using lithium diisopropylamine/hexamethylphosphoric triamide.Acetylation of the reaction products at room temperature yields the 3-acetoxy-6-alkylc
Pyrazolopyridine cycloalkanones and process for their preparation
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, (2008/06/13)
Novel tetrahydropyrazolo-[3,4-b]quinolinones, cyclopenta[b]pyrazolo-[4,3-e]pyridinones and cyclohepta[b]-pyrazolo[4,3-e]pyridinones, useful as anxiolytics having reduced side effects, are disclosed, including methods of preparation, pharmaceutical compositions containing them and intermediates used in their preparation.
N-ALKYLATION OF ENAMINONES
Greenhill, John V.,Moten, Ashraf M.
, p. 3405 - 3408 (2007/10/02)
The base catalyzed N-alkylation of a series of primary and secondary enaminones has been examined in detail.The enaminone anion was found to be a weak nucleophile.Best results were obtained in tetrahydrofuran or dioxane with sodium hydride and an alkyl io
