956593-48-9

Upstream product

• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 1086400-86-3 2-{(methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amino}-1-(4-methylsulfanyl-phenyl)-ethan-1-one 
• 1086400-85-2 (methyl)[3-(3-(piperidin-1-ylmethyl)phenoxy)benzyl]amine 
• 1086400-83-0 {3-[3-(piperidin-1-ylmethyl)phenoxy]phenyl}methanol 
• 1086400-84-1 3-[3-(piperidin-1-ylmethyl)phenoxy]benzaldehyde 
• 1778-09-2 4-(Methylthio)acetophenone 
• 3132-99-8 m-bromobenzoic aldehyde 
• 59507-40-3 1-(3-bromobenzyl)piperidine 
• 110-89-4 piperidine 
• 892408-41-2 2-methyl-4-(4-methylsulfanyl-phenyl)-1,2,3,4-tetrahydro-isoquinolin-7-ol 

Downstream Products

• 1086400-79-4 2-methyl-4-(4-(methylsulfanyl)phenyl)-7-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline trifluoroacetic acid salt 
• 1086400-82-9 2-methyl-4-(4-(methylsulfanyl)phenyl)-5-(3-(piperidin-1-ylmethyl)phenoxy)-1,2,3,4-tetrahydroisoquinoline trifluoroacetic acid salt 

Relevant academic research and scientific papers

DIARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AS HISTAMINE H3RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS

Certain diaryl-substituted tetrahydroisoquinoline compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.

Dual serotonin transporter inhibitor/histamine H3 antagonists: Development of rigidified H3 pharmacophores

A series of tetrahydroisoquinolines acting as dual serotonin transporter inhibitor/histamine H3 antagonists is described. The introduction of polar aromatic spacers as part of the histamine H3 pharmacophore was explored. A convergent synthesis of the final products allowing late stage introduction of the aromatic side chain was developed. In vitro and in vivo data are discussed.