89244-40-6Relevant articles and documents
N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS
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Page/Page column 76, (2010/11/05)
The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.
Synthesis of (+)-varitriol analogues via novel and versatile building blocks based on julia olefination
Senthilmnrugan, Annamalai,Aidhen, Indrapal Singh
scheme or table, p. 555 - 564 (2010/04/24)
The synthesis of (+)-varitriol (1) analogues was achieved through, the use of Julia olefination. The potential anticancer properties of 1 coupled with, our interest in developing building blocks that enable olefin formation under the Julia protocol constitute the basis of our research project. Efforts are aimed at the synthesis of building blocks 2 and 3 and to explore their use towards the synthesis of (+)-varit:riol analogues. Herein, we would, like to present the synthesis of building block 3 and its ability to react with variety of substituted aromatic-, heterocyclic- and carbohydrate-derived aldehydes to yield alkene 6 in moderate to good yields with E as the major isomer. The successful, coupling of 2 with (furanoside moieties) aldehydes 5k, 5m and 5n in particular and the obtainment of compound 23 reflect the promise associated with the new strategy.
NITROGENOUS HETEROCYCLIC DERIVATIVE HAVING 2,6-DISUBSTITUTED STYRYL
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Page/Page column 15, (2010/02/14)
The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.
Oxime O-ether compounds and fungicides for agricultural and horticultural use
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, (2008/06/13)
The present invention relates to novel oxime O-ether compounds represented by a general formula [I]; wherein R1represents C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy, etc., m represents an integer of 1 to 4, R2/
Nuclear versus Side-Chain Bromination of Methyl-Substituted Anisoles by N-Bromosuccinimide
Gruter, Gert-Jan M.,Akkerman, Otto S.,Bickelhaupt, Friedrich
, p. 4473 - 4481 (2007/10/02)
The reactions of methyl-substituted anisoles with N-bromosuccinimide in CCl4 are reported.In the absence of a catalyst and under irradiation, some of these substrates undergo nuclear bromination in competition with the well-known side-chain bromination.With 2-methylanisole and with 2,6-dimethylanisole, nuclear bromination is not observed, whereas with 3,5-dimethylanisole, nuclear bromination at the 4-position is the dominating reaction.Investigation of the reactivity of several other methyl-substituted anisoles revealed the following general trend: methyl-substituted anisoles are attacked at the position para to the methoxy group rather than at the side chain when (at least) two methyl groups are present at positions 3 and 5.When positions 2 and 6 are both occupied, nuclear bromination is retarded; in 2,6-dimethylanisole and 2,3,6-trimethylanisole, only side-chain bromination is observed.In contrast, in 2,3,5,6-tetramethylanisole, the 4-position is sufficiently reactive to be brominated, because the decrease in reactivity by the presence of two methyl groups at positions 2 and 6 is overruled by the two additional methyl groups at positions 3 and 5; as a result, both nuclear and side-chain bromination occur.The observed chemospecificity can be rationalized by a difference in mechanism: the side-chain bromination is radical reaction, while the nuclear bromination is an electrophilic aromatic substitution reaction, which is so far contrary to expectation, as irradiation had been expected to favor radical processes.
THE SELECTIVE BENZYLIC BROMINATION OF o-XYLENES. A USEFUL SYNTHESIS OF PHTHALIDES
Box, Vernon, G. S.,Yiannikouros, George P.
, p. 1261 - 1270 (2007/10/02)
The free radical bromination of aryl methyl groups can be controlled by the strategic positioning of a remote stereo-electronic blocking group on the aryl ring.This tactic leads to the efficient synthesis of selectively benzylically brominated molecules which are useful synthetic intermediates.This methodology has been applied to the synthesis of some phthalides.
