6161-65-5

Basic information

• Product Name: 2-Methoxy-6-methylbenzoic acid
• Synonyms: 2-Methoxy-6-methylbenzoic acid;2-Methyl-6-methoxybenzoic acid;6-Methoxy-2-methylbenzoic acid;6-Methoxy-o-toluic acid;2-Methoxy-6-methylbenzoic acid ,97%;2-methoxy-6-methylbenzoic acid(SALTDATA: FREE);Benzoic acid, 2-Methoxy-6-Methyl-
• CAS NO: 6161-65-5
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• Mol File: 6161-65-5.mol
• Article Data: 22

Chemical Properties

• Melting Point: 137-138 °C
• Boiling Point: 295.837 °C at 760 mmHg
• Flash Point: 119.357 °C
• Appearance: /
• Density: 1.168 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.74±0.31(Predicted)
• CAS DataBase Reference: 2-Methoxy-6-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-6-methylbenzoic acid(6161-65-5)
• EPA Substance Registry System: 2-Methoxy-6-methylbenzoic acid(6161-65-5)

Safety Data

• Hazardous Substances Data: 6161-65-5(Hazardous Substances Data)

Usage

General Description

2-Methoxy-6-methylbenzoic acid is a chemical compound with the molecular formula C9H10O3. It is a derivative of benzoic acid and contains a methoxy group and a methyl group attached to the benzene ring. 2-Methoxy-6-methylbenzoic acid is commonly used in organic synthesis and pharmaceutical research. It has potential applications in the production of pharmaceutical drugs and as an intermediate in the synthesis of various organic compounds. 2-Methoxy-6-methylbenzoic acid is a white crystalline solid with a melting point of 141-143°C and is soluble in organic solvents such as ethanol and ethyl acetate. It is important to handle this compound with caution and adhere to proper safety protocols when working with it.

InChI:InChI=1/C9H10O3/c1-6-4-3-5-7(12-2)8(6)9(10)11/h3-5H,1-2H3,(H,10,11)

Upstream product

• 33528-09-5 methyl 6-methylsalicylate 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 18595-13-6 2-amino-6-methylbenzoic acid methyl ester 
• 61940-22-5 methyl 2-methyl-6-nitrobenzoate 
• 50868-73-0 2-methoxy-6-methylbenzeneamine 
• 108-39-4 3-methyl-phenol 
• 5345-42-6 1-methoxy-3-methyl-2-nitro-benzene 
• 4920-77-8 3-methyl-2-nitrophenol 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 95330-45-3 N-tert-Butyl-N-methyl-2-methoxy-6-methylbenzamide 
• 95330-46-4 N-tert-Butyl-N-methyl-2-methoxybenzamide 
• 95330-31-7 2-methoxy-6,N-dimethylbenzamide 
• 89244-40-6 2-(Bromomethyl)-3-methylanisole 

Downstream Products

• 135691-03-1 4,5-Dihydro-2-(2-methoxy-6-methylphenyl)oxazole 
• 233606-12-7 N-(2-chloroethyl)-2-methoxy-6-methylbenzamide 
• 135691-02-0 N-(2-Hydroxyethyl)-2-methoxy-6-methylbenzamide 
• 135691-08-6 (1'S,3S)-3-(1-Benzyloxycarbonylamino-3-methylbutyl)-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one 
• 135691-05-3 ((S)-1-{2-[2-(4,5-Dihydro-oxazol-2-yl)-3-methoxy-phenyl]-1-hydroxy-ethyl}-3-methyl-butyl)-carbamic acid benzyl ester 
• 135691-07-5 (1'R,3S)-3-(1-Benzyloxycarbonylamino-3-methylbutyl)-3,4-dihydro-8-methoxy-1H-2-benzopyran-1-one 
• 135691-06-4 (1'S,3S)-3-(1-Benzyloxycarbonylamino-3-methylbutyl)-3,4-dihydro-8-methoxy-1H-2-benzopyran-1-one 
• 109987-17-9 ethyl (2-methoxy-6-methylbenzoyl)acetoacetate 
• 21499-23-0 phyllodulcin 
• 946001-61-2 (1R)-2-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-1-(p-tolyl)ethanol 
• 946001-52-1 (S)-4-isopropyl-2-(2-methoxy-6-methylphenyl)-4,5-dihydrooxazole 
• 946002-05-7 (R)-8-hydroxy-3-(4-methoxy-3-(methoxymethoxy)phenyl)-3,4-dihydroisocoumarin 
• 946001-97-4 (1R)-2-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanol 
• 946001-82-7 (2S)-1-{2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-3-methoxyphenyl}-2-pentadecanol 

Relevant articles and documents

Preparation method of 2-methoxy-6-methylbenzoic acid

The invention discloses a synthesis process of 2-methoxy-6-methylbenzoic acid, which comprises the following steps: (1) reduction hydrogenation reaction: by taking 2-methyl-6-nitrobenzoic acid or methyl 2-methyl-6-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst, carrying out hydrogenation reduction to prepare 2-amino-6-methylbenzoic acid or methyl 2-amino-6-methylbenzoate; (2) diazotization, hydrolysis and esterification one-pot reaction: by taking the reduction product as a raw material, and methanol as a solvent, performing diazotization, hydrolysis and esterification reaction under the action of a diazotization reagent to prepare methyl 2-hydroxy-6-methylbenzoate; (3) methylation reaction: with methyl 2-hydroxy-6-methylbenzoate as a raw material and dimethyl sulfate as a methylation reagent, carrying out methylation reaction in the presence of alkali to prepare methyl 2-methoxy-6-methylbenzoate; and (4) hydrolysis reaction: mixing the methyl 2-methoxy-6-methylbenzoate with alkali and water, conducting heating for hydrolysis, conducting cooling after the reaction is completed, adjusting the pH value to 1-3 by using acid, separating out a product, and conducting filtering and drying to obtain the 2-methoxy-6-methylbenzoic acid.

HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF

The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

Original preparation of conjugates for antibody production against Amicoumacin-related anti-microbial agents

Amicoumacins are natural products with potent anti-ulcerogenic and anti-bacterial activities, and have been isolated from different Bacillus genera. They belong to a family of 3,4-dihydroisocoumarin derivatives bearing hydroxylated amino acid side chains.