89250-13-5Relevant academic research and scientific papers
Formamidine derivatives and pharmaceutical use
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, (2008/06/13)
Compounds of the formula STR1 wherein R is hydrogen or methyl; R1 is straight or branched alkyl of 1 to 6 carbon atoms, dimethyldioxolylmethyl, hydroxymethyldioxolylmethyl, hydroxy(alkyl of 1 to 6 carbon atoms), mono- or di-(alkoxy of 1 to 6 ca
Ionization, tautomerism and molecular conformation in aqueous solution of the histamine H2-receptor antagonist mifentidine
Bazzano,Vavoni,Mondoni,et al.
, p. 27 - 33 (2007/10/02)
Ionization (pK(a)) and tautomeric (K(t)) constants of mifentidine (DA4577) have been determined in aqueous solution. The predominant molecular species at physiological pH (7.4) is the monocationic form (95.3%) at the formamidine moiety, with the imidazole
