89250-15-7Relevant articles and documents
HYDRAZONE DERIVATIVE
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Page/Page column 29, (2010/11/08)
A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof
Ionization, tautomerism and molecular conformation in aqueous solution of the histamine H2-receptor antagonist mifentidine
Bazzano,Vavoni,Mondoni,et al.
, p. 27 - 33 (2007/10/02)
Ionization (pK(a)) and tautomeric (K(t)) constants of mifentidine (DA4577) have been determined in aqueous solution. The predominant molecular species at physiological pH (7.4) is the monocationic form (95.3%) at the formamidine moiety, with the imidazole