312925-73-8Relevant academic research and scientific papers
Continuous flow synthesis of secondary amides by tandem azidation-amidation of anilines
Spiteri, Christian,Moses, John E.
, p. 1546 - 1548 (2012)
The continuous flow synthesis of a variety of secondary amides by tandem azidation-amidation of anilines is described. This new procedure benefits from the improved safety feature of generating aromatic azides in flow, thus ensuring low concentrations of any potentially hazardous intermediates. The protocol was amenable to the production of multi-gram quantities of the amide product. Georg Thieme Verlag Stuttgart · New York.
Synthesis and anticancer activities of some thiazole derivatives
Kayagil, Ismail,Demirayak, Seref
scheme or table, p. 2197 - 2207 (2010/04/24)
In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl)aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2- yl]amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.
