89258-55-9

Upstream product

• 98-88-4 benzoyl chloride 
• 609-85-8 2-amino-3,5-dibromobenzoic acid 

Downstream Products

• 1006386-69-1 2-chloro-N-(6,8-dibromo-4-oxo-2-phenyl-quinazolin-3(4H)-yl)-acetamide 
• 1048968-60-0 3-(4-(dimethylamino)benzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-71-9 3-(3-phenylallylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-70-8 3-(4-hydroxy-3-methoxybenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-63-9 3-(2-hydroxybenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 143835-55-6 3-(4-methoxybenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-66-2 3-(4-hydroxybenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 143835-52-3 3-(benzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-69-5 3-(3,4,5-trimethoxybenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-68-4 3-(4-nitrobenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-64-0 3-(3-nitrobenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-67-3 3-(4-chlorobenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1155404-65-1 3-(4-methylbenzylideneamino)-6,8-dibromo-2-phenylquinazolin-4(3H)-one 
• 1006595-08-9 C₁₉H₁₀Br₂N₄O₄ 

Relevant academic research and scientific papers

Dihydrofolate reductase inhibitors: Synthesis, characterization and biological evaluation of some novel 2,3-disubstituted quinazolinones

A series of some novel dihydrofolate reductase inhibitors (DHFR) of 2,3-disubstituted quinazolinone derivatives were synthesized by condensing benzoxazone derivatives with compounds containing primary amino group. The chemical structures of the newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, Mass spectral data and elemental analysis. The enzyme inhibitory activities were studied by using GLIDE 4.5 module. In vitro cytotoxic activity of the synthesized compounds was evaluated by MTT assay method. Compounds 3g and 5a exhibited good hydrogen bond interactions with the amino acid residue of DHFR and also showed significant cytotoxic activity.