89263-98-9

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 79-38-9 Chlorotrifluoroethylene 
• 591-51-5 phenyllithium 
• 1427-33-4 1,1,2-trifluoro-2-trimethylsilylethylene 

Downstream Products

• 89264-07-3 difluoro-1,2 dimethyl-3,3 phenyl-1 butene-(E) 
• 89264-08-4 difluoro-1,2 dimethyl-3,3 (p-t-butylphenyl)-1 butene-(E) 
• 111833-30-8 fluoro-1 (methyl-1 cyclohexyl)-1 acetophenone 
• 102676-04-0 ethyl (E)-2,3-difluoro-3-phenyl-2-propenoate 
• 64325-22-0 (E)-1,2-difluoro-1-lithio-2-phenylethene 
• 90786-33-7 difluoro-1,2 methyl-2 phenyl-1 ethylene-(E) 
• 19706-75-3 (Z)-β-iodo-α,β-difluorostyrene 
• 106325-42-2 fluoro-2 dimethyl-3,3 phenyl-1 butanone-1 
• 123746-78-1 difluoro-1,2 phenyl-2 trimethylsilyl-1 oxiranne 
• 132067-94-8 ((1R,2R)-1,2-Dibromo-1,2-difluoro-2-phenyl-ethyl)-trimethyl-silane 
• 132067-94-8 1,2-difluoro 1,2-dibromo 1-trimethylsilyl 2-phenyl ethylene 
• 132068-26-9 1,2-difluoro 1-bromo 2-phenyl ethylene 
• 132093-28-8 trans-1-bromo-1,2-difluoro-2-phenylethene 
• 132068-25-8 1,1,2-tribromo 1,2-difluoro 2-phenyl ethane 

Relevant academic research and scientific papers

A Novel Stereospecific Route to (E)- And (Z)-(2-Substituted-1,2-difluoroethenyl)stannanes

In the presence of 1.2-1.5 equiv of potassium fluoride, a variety of (E)- and (Z)-(2-substituted-1,2-difluoroethenyl)silanes reacted with tributyltin chloride in DMF at room temperature to 80 °C to afford the corresponding stannanes in good yields with overall retention of configuration. These stannanes are useful intermediates for the introduction of the (E)- and (Z)-1,2-difluoroethylene unit into organic molecules. Under similar reaction conditions, only catalytic potassium fluoride (5-10%) was needed for these conversions when tributyltin chloride was replaced by tributyltin oxide. The mechanism and scope of this transformation is discussed.

A novel synthetic route to ethyl 3-substituted-trans-2,3-difluoro-2-acrylates and their reactions with nucleophiles

Reaction of a variety of trans-1-trimethylsilyl-1,2-difluoroalkenes with ethyl chloroformate in the presence of potassium fluoride gave the corresponding ethyl 3-substituted-trans-2,3-difluoro-2-acrylates in good yields, which reacted with a variety of nucleophiles such as hydrazine hydrate, amidines and thiourea etc. in the presence of bases to afford the corresponding 4-fluoropyrazole, 5-fluoropyrimidine and 5-fluoro-2-uracil derivatives in good yields. (C) 2000 Elsevier Science Ltd.

SYNTHESE DE DIFLUOROALCENES-trans

Several trans-difluoro olefins have been prepared from chlorotrifluoroethylene via difluorovinylsilicon intermediates.

SYNTHESE DE DIFLUOROOLEFINES TRANS

Trans difluoroolefins have been prepared from chlorotrifluoroethylene.