89266-26-2Relevant academic research and scientific papers
One-Step Synthesis of Triphenylphosphonium Salts from (Het)arylmethyl Alcohols
Abaev, Vladimir T.,Chalikidi, Petrakis N.,Demidov, Oleg P.,Gutnov, Andrey V.,Magkoev, Taimuraz T.,Trushkov, Igor V.,Uchuskin, Maxim G.
, p. 9838 - 9846 (2021/07/28)
Two approaches for the synthesis of substituted phosphonium salts from easily available benzyl alcohols and their heterocyclic analogs have been developed. The developed protocols are complementary: the direct mixing of alcohol, trimethylsilyl bromide, and triphenylphosphine in 1,4-dioxane followed by heating at 80 °C was found to be more efficient for acid-sensitive substrates, such as salicyl or furfuryl alcohols as well as secondary benzyl alcohols, while a one-pot procedure including sequential addition of trimethylsilyl bromide and triphenylphosphine gave higher yields for benzyl alcohols bearing electroneutral or electron-withdrawing substituents.
Research on nitro derivatives of biological interest. XXXIII. Synthesis and action on microorganisms of 5-nitrofurylic and 5-nitro thienylic benzofuran derivatives
Guillaumel,Royer,Le Corre,et al.
, p. 431 - 436 (2007/10/02)
Quite a number of benzofurans substituted at the 2-position by a 5-nitrofuryl, 5-nitrothienyl, 5-nitro 2-furyl ethenyl or 5-nitro 2-thienyl ethenyl group were prepared by heterocyclization of 2-acyloxy benzyltriphenylphosphonium bromides derivated from 2-hydroxy benzyl triphenylphosphonium bromides, themselves obtained by action of triphenylphosphine bromhydrate on ortho hydroxylated benzyl alcohols. Besides, several 5-nitro 2-furoyl benzofurans were also obtained by condensation of diversely substituted salicylaldehydes and 2-bromacetyl 5-nitrofuran. Most of these new benzofuran heterocyclic nitro derivatives are deprived of the parasiticidic and antibacterial properties owned by 2-nitro benzofurans.
