89266-34-2Relevant academic research and scientific papers
Research on nitro derivatives of biological interest. XXXIII. Synthesis and action on microorganisms of 5-nitrofurylic and 5-nitro thienylic benzofuran derivatives
Guillaumel,Royer,Le Corre,et al.
, p. 431 - 436 (2007/10/02)
Quite a number of benzofurans substituted at the 2-position by a 5-nitrofuryl, 5-nitrothienyl, 5-nitro 2-furyl ethenyl or 5-nitro 2-thienyl ethenyl group were prepared by heterocyclization of 2-acyloxy benzyltriphenylphosphonium bromides derivated from 2-hydroxy benzyl triphenylphosphonium bromides, themselves obtained by action of triphenylphosphine bromhydrate on ortho hydroxylated benzyl alcohols. Besides, several 5-nitro 2-furoyl benzofurans were also obtained by condensation of diversely substituted salicylaldehydes and 2-bromacetyl 5-nitrofuran. Most of these new benzofuran heterocyclic nitro derivatives are deprived of the parasiticidic and antibacterial properties owned by 2-nitro benzofurans.
