89268-62-2

Basic information

• Product Name: FAMOTIDINE RELATED COMPOUND B
• Synonyms: Famotidine EP Impurity B;FAMOTIDINE RELATED COMPOUND B;3,5-Bis[2-[[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]thio]-ethyl]-4H-1,2,4,6-thiatriazine-1,1-dioxide;Famotidine Related Compound B (25 mg) (3,5-bis[2-[[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]sulphany]ethyl]-4H-1,2,4,6-thiatriazine1,1-dioxide) (AS);N,N'''-[(1,1-Dioxido-2H-1,2,4,6-thiatriazine-3,5-diyl) bis(2,1-ethanediylthioMethylene-4,2-thiazolediyl)]bisguanidi;FaMotidine EP IMpurity B (USP RC B);2-[4-[2-[5-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1,1-dioxo-4H-1,2,4,6-thiatriazin-3-yl]ethylsulfanylmethyl]-1,3-thiazol-2-yl]guanidine;3,5-bis[2-[[[2-[(Diaminomethylene)amino]thiazol-4-yl]methyl]sulphanyl]ethyl]-4H-1,2,4,6-thiatriazine 1,1-dioxide
• CAS NO: 89268-62-2
• Molecular Formula: C16H23N11O2S5
• Molecular Weight: 561.75132
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 89268-62-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 782.835°C at 760 mmHg
• Flash Point: 427.243°C
• Appearance: /
• Density: 1.856g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.881
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: FAMOTIDINE RELATED COMPOUND B(CAS DataBase Reference)
• NIST Chemistry Reference: FAMOTIDINE RELATED COMPOUND B(89268-62-2)
• EPA Substance Registry System: FAMOTIDINE RELATED COMPOUND B(89268-62-2)

Safety Data

• Hazardous Substances Data: 89268-62-2(Hazardous Substances Data)

Usage

Chemical Properties

FAMOTIDINE RELATED COMPOUND B is White to Off-White Powder

Uses

Different sources of media describe the Uses of 89268-62-2 differently. You can refer to the following data:
1. FAMOTIDINE RELATED COMPOUND B is an impurity of Famotidine, which is used as an H2-antagonist, an anti-ulcer agent
2. Famotidine Related Compound B (Famotidine EP Impurity B) is an impurity of Famotidine.

InChI:InChI=1/C16H23N11O2S5/c17-13(18)24-15-21-9(7-32-15)5-30-3-1-11-23-12(27-34(28,29)26-11)2-4-31-6-10-8-33-16(22-10)25-14(19)20/h7-8H,1-6H2,(H,23,26,27)(H4,17,18,21,24)(H4,19,20,22,25)

Upstream product

• 76823-94-4 methyl 3-<<<2-<(diaminomethylene)amino>-4-thiazolyl>methyl>thio>propionimidate 

Relevant articles and documents

Studies on Histamine H2 Receptor Antagonists. 2. Synthesis and Pharmacological Activities of N-Sulfamoyl and N-Sulfonyl Amidine Derivatives

A series of N-sulfamoyl and N-sulfonyl amidines have been prepared and tested in vitro for H2 antihistamine activity on quinea pig atrium.In addition, several selected compounds were assessed as inhibitors of gastric acid secretion induced by histamine in anesthetized dogs.Structure-activity relationship studies showed that those compounds containing 2-thiazole exhibited potent H2-receptor antagonist activity.Introduction of alkyl or aralkyl groups to the terminal nitrogen of the sulfamoyl moiety reduced biological activities.Sulfamoyl amidines were more potent in both tests than sulfonyl amidines.Of these compounds, 3--4-thiazolyl>methyl>thio>-N2-sulfamoylpropionamide (2e, famotidine) showed extremely high potency in both assays and was selected for clinical trials as an antiulcer agent.Acid-catalyzed hydrolysis of famotidine gave the sulfamoyl amide 6 at room temperature and the carboxylic acid 7 at elevated temperatures. 15 N NMR spectrum showed that famotidine in solution existed in only one of several possible tautomers derived from the amidine and the guanidine moieties.Nitrosation of famotidine was performed under mild condition and proved to occur on the 5-position of the thiazole ring.