89270-65-5

Upstream product

• 14763-24-7 (2,6-dichlorophenyl)hydrazine 
• 49664-33-7 2,7-dimethyl-4H,9H-dipyrazolo<1,5-a,1',5'-d>pyrazine-4,9-dione 
• 64-18-6 formic acid 
• 89270-45-1 5-Methyl-2H-pyrazole-3-carboxylic acid N'-(2,6-dichloro-phenyl)-hydrazide 

Downstream Products

• 94447-39-9 C₁₄H₁₂Cl₂N₄O₃ 

Relevant academic research and scientific papers

Pyrazolecarboxylic acid hydrazides as antiinflammatory agents. New selective lipoxygenase inhibitors

The synthesis and antiinflammatory activity of some new pyrazolecarboxylic acid hydrazides 3, 4 and 5 substituted with alkyl, alkylidene, aryl and acyl groups are described. 3 were prepared by reaction of pyrazolecarboxylic acids, esters, acid chlorides or diketopiperazines with hydrazines. Upon reaction with carbonyl compounds 3 gave hydrazones 4. Acylation of 3 yielded mono or bisacyl compounds 5. The most potent antiinflammatory compounds were among the N'-aryl hydrazides. These showed high lipoxygenase inhibitory activity but hardly inhibited cyclooxygenase enzyme.