89273-00-7Relevant academic research and scientific papers
Synthesis, biological evaluation and modeling studies of dual binding AChE inhibitors
Castro, Ana,Hernandez, Laura,Dorronsoro, Isabel,Saenz, Patricia,Perez, Concepcion,Kalko, Susana,Orozco, Modesto,Luque, F. Javier,Martinez, Ana
, p. 219 - 237 (2007/10/03)
A receptor-based pharmacophore, previously derived using de novo ligand design technique, has been employed to design dual binding site acetylcholinesterase (AChE) inhibitors. The synthesis of the resultant substituted imidazoles followed by the correspon
