89280-54-6Relevant academic research and scientific papers
Diverse ring opening of thietanes and other cyclic sulfides: An electrophilic aryne activation approach
Zheng, Tianyu,Tan, Jiajing,Fan, Rong,Su, Shuaisong,Liu, Binbin,Tan, Chen,Xu, Kun
supporting information, p. 1303 - 1306 (2018/02/14)
Organosulfides are a common class of structure units in bioactive molecules and functional materials motivating continuous developments of efficient synthetic methods. Herein, we report an electrophilic aryne-activated ring opening protocol of one or two
Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry
Burkhard, Johannes A.,Guerot, Carine,Knust, Henner,Rogers-Evans, Mark,Carreira, Erick M.
supporting information; experimental part, p. 1944 - 1947 (2010/07/04)
Figure presented Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.
