89283-48-7

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-6-METHYLTHIOPYRIMIDINE is used as a building block for the synthesis of various pharmaceuticals. It plays a crucial role in the production of antihypertensive drugs, which are essential for treating high blood pressure and related cardiovascular conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-6-METHYLTHIOPYRIMIDINE is utilized as a key component in the development of veterinary medicines. These medicines are vital for maintaining the health and well-being of animals in various agricultural settings.
Used in Herbicide Production:
4-CHLORO-6-METHYLTHIOPYRIMIDINE is also employed in the synthesis of herbicides, which are chemicals used to control, kill, or inhibit the growth of unwanted plants in agricultural fields, gardens, and other areas. Its use in herbicide production helps to improve crop yields and protect valuable plant resources from invasive species.

InChI:InChI=1/C5H5ClN2S/c1-9-5-2-4(6)7-3-8-5/h2-3H,1H3

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 5188-07-8 sodium thiomethoxide 
• 353-43-5 boron dimethyl-trifluoro sulphide 

Downstream Products

• 89283-46-5 4-chloro-6-(methylsulfonyl)pyrimidine 
• 1018473-16-9 N-(3-(2-(6-methanesulfinylpyrimidin-4-yl)-5-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide 
• 1018467-70-3 N-(4-methyl-3-(5-methyl-2-(6-methylsulfanylpyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide 
• 1193-21-1 4,6-dichloropyrimidine 
• 99469-77-9 (6-methylsulfanylpyrimidin-4-yl)hydrazine 
• 1035558-77-0 4-methylsulfanyl-6-(4-nitro-phenoxy)-pyrimidine 
• 89125-96-2 6-Jod-4-methylmercapto-pyrimidin 

Relevant academic research and scientific papers

BF3·SMe2 for Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles

Herein, a general, solvent-free and straightforward thiomethylation of electron deficient heterocycles using BF3·SMe2 as a dual thiomethyl source and Lewis acidic activator is presented. A range of heterocycles including pyrimidine, pyrazine, pyridazine, thiazole and purine derivatives were successfully substituted using this method. An unexpected reductive property of BF3·SMe2 towards nitropyridines was also discovered including an intriguing tandem reduction/SMe insertion process in certain substrates. Notable features of the present work include its convenience and use of a non-malodorous reagent while the discovery of novel chemical transformations using BF3·SMe2 provides fundamental new insights into the reactivity of this commonly employed reagent.

Synthesis of Alkylated Pyrimidines via Photoinduced Coupling Using Benzophenone as a Mediator

The synthesis of alkylated pyrimidines was achieved via benzophenone-mediated photoinduced coupling between saturated heterocycles and sulfonylpyrimidines. The pyrimidine ring was selectively introduced at the nonacidic C(sp3)-H bond proximal to heteroatoms including oxygen, nitrogen, and sulfur. This is a coupling reaction mediated solely by photoexcited benzophenone, an organic molecule, without the aid of any metallic catalysts or reagents.

INDOLE AND AZAINDOLE MODULATORS OF THE ALPHA 7 NACHR

This invention relates to modulation of the α7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a pharmaceutically acceptable salt thereof.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

PYRAZOLO [1,5-a] PYRIMIDINES USEFUL AS JAK2 INHIBITORS

The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

Constitutive activation of the EPO/JAK2 signaling cascade has recently been implicated in a variety of myeloproliferative disorders including polycythemia vera, essential thrombocythemia and myelofibrosis. In an effort to uncover therapeutic potential of blocking the EPO/JAK2 signaling cascade, we sought to discover selective inhibitors that block the kinase activity of JAK2. Herein, we describe the discovery and structure based optimization of a novel series of 2-amino-pyrazolo[1,5-a]pyrimidines that exhibit potent inhibition of JAK2.

PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS

Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as w

[4,5']BIPYRIMIDINYL-6,4'-DIAMINE DERIVATIVES AS PROTEIN KINASE INHBITORS

The invention provides a novel class of compounds of the Formula (I): in which the symbols have the meanings given in the description and claims, to pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prev

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly di