89284-39-9

Basic information

• Product Name: 3-Amino-4,5-dichloropyridine
• Synonyms: 3-Amino-4,5-dichloropyridine;4,5-dichloropyridin-3-aMine;4,5-Dichloro-3-pyridinamine;4,5-Dichloro-pyridin-3-ylamine
• CAS NO: 89284-39-9
• Molecular Formula: C₅H₄Cl₂N₂
• Molecular Weight: 163
• Product Categories: pharmacetical
• Mol File: 89284-39-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Amino-4,5-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4,5-dichloropyridine(89284-39-9)
• EPA Substance Registry System: 3-Amino-4,5-dichloropyridine(89284-39-9)

Safety Data

• Hazardous Substances Data: 89284-39-9(Hazardous Substances Data)

Usage

General Description

3-Amino-4,5-dichloropyridine is a chemical compound with the molecular formula C5H4Cl2N2. 3-Amino-4,5-dichloropyridine belongs to the class of organic compounds known as dichlorobenzenes, characterized by a benzene with exactly two chlorine atoms attached to it. It exists as a powder form at room temperature and is generally known for its use in the synthesis of other chemical reactions. The typical handling precautions for organic compounds apply to it—avoiding inhalation, ingestion, and skin contact—due to its potentially hazardous nature.

Upstream product

• 5435-54-1 4-hydroxy-3-nitropyridine 

Relevant articles and documents

7′-Substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors

We report on the discovery of benzo- and pyridinothiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions on the aromatic ring with a 7′-substituent essential for activity. Some of these compounds exhibit low nanomolar inhibition activity in a Her-2 degradation assay (28-150 nM), good aqueous solubility, and oral bioavailability profiles in mice. In vivo efficacy experiments demonstrate that compounds of this class inhibit tumor growth in an N87 human colon cancer xenograft model via oral administration as shown with compound 37 (8-(7-chloro-benzothiazol-2-ylsulfanyl)-9-(2-cyclopropylamino-ethyl) -9H-purin-6-ylamine).