89284-39-9 Usage
Uses
Used in Pharmaceutical Industry:
3-Amino-4,5-dichloropyridine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of derivatives, making it a valuable building block in the development of new drugs.
Used in Chemical Synthesis:
3-Amino-4,5-dichloropyridine is used as a reagent in the synthesis of other organic compounds. Its presence in chemical reactions can lead to the formation of new molecules with different properties, contributing to the advancement of organic chemistry.
Used in Research and Development:
3-Amino-4,5-dichloropyridine is used as a research compound in academic and industrial laboratories. Its properties and reactivity are studied to understand its potential applications and to develop new methods for its synthesis and use in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 89284-39-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,2,8 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 89284-39:
(7*8)+(6*9)+(5*2)+(4*8)+(3*4)+(2*3)+(1*9)=179
179 % 10 = 9
So 89284-39-9 is a valid CAS Registry Number.
89284-39-9Relevant academic research and scientific papers
7′-Substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors
Zhang, Lin,Fan, Junhua,Vu, Khang,Hong, Kevin,Le Brazidec, Jean-Yves,Shi, Jiandong,Biamonte, Marco,Busch, David J.,Lough, Rachel E.,Grecko, Roy,Ran, Yingqing,Sensintaffar, John L.,Kamal, Adeela,Lundgren, Karen,Burrows, Francis J.,Mansfield, Robert,Timony, Gregg A.,Ulm, Edgar H.,Kasibhatla, Srinivas R.,Boehm, Marcus F.
, p. 5352 - 5362 (2007/10/03)
We report on the discovery of benzo- and pyridinothiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions on the aromatic ring with a 7′-substituent essential for activity. Some of these compounds exhibit low nanomolar inhibition activity in a Her-2 degradation assay (28-150 nM), good aqueous solubility, and oral bioavailability profiles in mice. In vivo efficacy experiments demonstrate that compounds of this class inhibit tumor growth in an N87 human colon cancer xenograft model via oral administration as shown with compound 37 (8-(7-chloro-benzothiazol-2-ylsulfanyl)-9-(2-cyclopropylamino-ethyl) -9H-purin-6-ylamine).
