892859-32-4Relevant articles and documents
Semisynthesis and biological evaluation of a novel D-seco docetaxel analogue
Thoret, Sylviane,Gueritte, Francoise,Guenard, Daniel,Dubois, Joelle
, p. 2301 - 2304 (2007/10/03)
A 4-methyl-5-oxo docetaxel analogue has been prepared starting from 10-deacetylbaccatin III. This new D-seco docetaxel analogue is slightly less potent than docetaxel at microtubule stabilization in vitro and has about 1/1000th the cytotoxicity of docetax