892964-57-7Relevant academic research and scientific papers
X-ray diffraction, solution structure, and computational studies on derivatives of (3-sec-butyl-2,3-dihydro-1H-isoquinolin-4-ylidene)acetic acid: Compounds with activity as calpain inhibitors
Alonso, Mercedes,Chicharro, Roberto,Miranda, Carlos,Aran, Vicente J.,Maestro, Miguel A.,Herradon, Bernardo
, p. 342 - 352 (2010)
(Chemical Equation Presented) A thorough experimental and computational study of derivatives of (3-sec-butyl-2,3-dihydroisoquinolin-4-ylidene)acetic acid was performed. Some of these compounds are calpain inhibitors and could be useful as therapeutic agen
ISOQUINOLINE DERIVATIVES AS CALPAIN INHIBITORS
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Page/Page column 8, (2010/11/28)
The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec-butyl group at position 3 with calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3-sec-butyl-1-oxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid and (3-sec-butyl-1-thioxo-2,3-dihydro-1H-isoquinolin-4-yliden)-acetic acid. Compounds having formula I or II can be used in the preventive or therapeutic treatment of a degenerative disease.
