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Usage

Uses

Used in Pharmaceutical Industry:
N-(2,2-dimethoxyethyl)-2-phenylacetamide is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new medicinal drugs. Its chemical structure allows for the formation of a wide range of compounds with potential therapeutic applications.
Used in Organic Compounds Synthesis:
In the realm of organic chemistry, N-(2,2-dimethoxyethyl)-2-phenylacetamide is employed as a building block for the production of various organic compounds. Its unique properties enable the creation of a diverse array of chemical entities with specific functionalities and applications.
Used in Specialty Chemicals Manufacturing:
Beyond its pharmaceutical applications, N-(2,2-dimethoxyethyl)-2-phenylacetamide may also find use in the industrial sector, particularly in the manufacturing of specialty chemicals. Its versatility and reactivity make it a valuable component in the production of certain chemical products that require specific characteristics for their intended applications.

Upstream product

• 103-82-2 phenylacetic acid 
• 22483-09-6 2,2-dimethoxyethylamine 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 92460-21-4 3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-1,3,4,5-tetrahydro-benzo[d]azepin-2-one 
• 19301-09-8 1,3-dihydro-benzo[d]azepin-2-one 

Relevant academic research and scientific papers

7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: Hit-to-lead optimization

New 7-sulfonamido-3-benzazepines 3 are disclosed as 5-HT2C receptor agonists. Appropriate substitution of the amino group (R1R2N-) gave compounds that were potent 5-HT2C agonists with minimal activation of the 5-HT2A and 5-HT2B receptors. Furthermore, representative examples had excellent in vitro ADME properties and good selectivity over ion channel activity.

Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties

Structural modification of the calcium-antagonist verapamil (1) by replacement of the lipophilic α-isopropylacetonitrile moiety by various heterocyclic ring systems has led to a new class of cardiovascular compounds which are characterized by a specific bradycardic activity. These agents reduce heart rate without binding to classical calcium channels or β-adrenoceptors, interacting instead specifically with structures at the sino atrial node. Therefore they have also been termed sinus node inhibition. The prototype falipamil (2) has been submitted to furthr optimization mainly hy manipulation of the phthalimidine moiety. This has resultd in a secod generation of specific bradycardic agents with increased potency and selectively and prolonged duration of action represented by the benzazepinone-derivative UL-FS 49 (4). Structure-activity relationships within this novel class of compounds have revealed a marked dependence of activity on the substitution pattern of the aromatic rings, the nature of the central nitrogen atom, and the length of the connecting alkyl chains. The crucial role of the benzazepione ring for bradycardic activity can be best explained by its special impact on the overall molecular conformation.