89353-42-4

Basic information

• Product Name: 3-(1H-Pyrrol-1-yl)aniline
• Synonyms: BUTTPARK 98\12-67;3-PYRROL-1-YL-ANILINE;3-PYRROL-1-YL-PHENYLAMINE;3-(1H-PYRROL-1-YL)ANILINE;1-(3-AMINOPHENYL)PYRROLE
• CAS NO: 89353-42-4
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Mol File: 89353-42-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 43 °C
• Boiling Point: 323.4 °C
• Flash Point: 149.4°C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 0.000263mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 3-(1H-Pyrrol-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-Pyrrol-1-yl)aniline(89353-42-4)
• EPA Substance Registry System: 3-(1H-Pyrrol-1-yl)aniline(89353-42-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 89353-42-4(Hazardous Substances Data)

Usage

General Description

3-(1H-Pyrrol-1-yl)aniline, also known as 1-(3-aminophenyl)pyrrole, is an organic compound with the molecular formula C10H10N2. It is a crystalline solid that is insoluble in water but soluble in organic solvents. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals, dyes, and other organic compounds. It is also known for its potential as a ligand for coordination chemistry and for its use in the production of hair dyes. 3-(1H-Pyrrol-1-yl)aniline is considered to be a versatile and important compound in the field of organic chemistry due to its structural and functional properties.

InChI:InChI=1/C10H10N2/c11-9-4-3-5-10(8-9)12-6-1-2-7-12/h1-8H,11H2

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 99-09-2 3-nitro-aniline 
• 109-97-7 pyrrole 
• 645-00-1 m-iodonitrobenzene 
• 108-45-2 m-phenylenediamine 
• 626-01-7 3-Iodoaniline 
• 4310-42-3 1-(3-nitrophenyl)-1H-pyrazole 

Downstream Products

• 1190222-46-8 methyl 5-chloro-2-{[(2-oxo-2-{[3-(1H-pyrrol-1-yl)phenyl]amino}ethoxy)acetyl]amino}benzoate 
• 1190221-33-0 5-chloro-2-([(2-oxo-2-([3-(1H-pyrrol-1-yl)phenyl]amino)ethoxy)acetyl]amino)benzoic acid sodium salt 
• 89353-43-5 diethyl 3-(1-pyrrolyl)anilinomethylenemalonate 

Relevant articles and documents

4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases inhibitors. The present invention also concerns these new inhibitors for use for the treatment of a condition selected in the group consisting of: cancers, virion infections, ocular hypertension and glaucoma formation, Neurofibromatosis type 1 and 2, psoriatic lesions, inflammatory diseases and hyperalgesia, central sensitization and chronic pain, reproduction erectile dysfunction, and neuronal diseases. The present description discloses the syntheses and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 32 to 127; examples 1 to 96; families 1 to 8; compounds; biological studies; tables). An exemplary compound is e.g. 4-(5-m ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-phenyl-3,6-dihydropyridine-1-(2H)-carboxamide (example 1; compound 5).

Novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application (by machine translation)

The invention relates to the general formula I shown novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application. The invention also provides pharmaceutical compositions containing them, in vitro and in vivo anti-tumor effect results and acute toxicity study, the obtained anti-tumor drug model substituted benzoyl compound, has more excellent anti-tumor activity and safety, can be in the treatment of leukemia, lung cancer, colon cancer, ovarian cancer and renal carcinoma tumor in the application, so that the therapeutic window, so in the medical field as antitumor agents in the very application value. (by machine translation)

Synthesis of heteroaromatic derivatives with nitrogen atoms: Tripyrrolyl pyrimidine and tripyrrolyl[1,3,5]triazine

As a part of a research program related to the synthetic study of pharmacologically and photoconductively interesting pyrrole derivatives, we have synthesized 1-arylpyrroles (3a-e), 9-arylcarbazoles (4a-e), aminophenylpyrroles (6a,b), dipyrrolylbenzenes (7a-c), 2,4,6-tri-pyrrol-1- yl-pyrimidine (8) and 2,4,6-tri-pyrrol-1-yl[1,3,5]triazine (9). We proposed a plausible mechanism for the formation of 9-arylcarbazole.