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Quinoline, 2,4,8-trichloro-7-methoxy-, is a highly chlorinated derivative of quinoline, characterized by the presence of three chlorine atoms and one methoxy group. It is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes, and has been studied for its potential biological activities, including anticancer, antimicrobial, and antifungal properties. Due to its versatile reactivity, it is also used as a building block in the synthesis of other complex organic compounds. However, it is important to handle this chemical with care as it is toxic to aquatic organisms and may cause long-term adverse effects in the environment.

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  • 893620-26-3 Structure
  • Basic information

    1. Product Name: Quinoline, 2,4,8-trichloro-7-methoxy-
    2. Synonyms: Quinoline, 2,4,8-trichloro-7-methoxy-;2,4,8-Trichloro-7-methoxyquinoline;8-trichloro-7-Methoxy-
    3. CAS NO:893620-26-3
    4. Molecular Formula: C10H6Cl3NO
    5. Molecular Weight: 262.52
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 893620-26-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 348.5 °C at 760 mmHg
    3. Flash Point: 164.5 °C
    4. Appearance: /
    5. Density: 1.486
    6. Vapor Pressure: 0.000101mmHg at 25°C
    7. Refractive Index: 1.638
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: -3.45±0.50(Predicted)
    11. CAS DataBase Reference: Quinoline, 2,4,8-trichloro-7-methoxy-(CAS DataBase Reference)
    12. NIST Chemistry Reference: Quinoline, 2,4,8-trichloro-7-methoxy-(893620-26-3)
    13. EPA Substance Registry System: Quinoline, 2,4,8-trichloro-7-methoxy-(893620-26-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 893620-26-3(Hazardous Substances Data)

893620-26-3 Usage

Uses

Used in Pharmaceutical Industry:
Quinoline, 2,4,8-trichloro-7-methoxy-, is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activities, including anticancer, antimicrobial, and antifungal properties.
Used in Agrochemical Industry:
Quinoline, 2,4,8-trichloro-7-methoxy-, is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Dye Industry:
Quinoline, 2,4,8-trichloro-7-methoxy-, is used as an intermediate in the synthesis of dyes, providing a wide range of color options for various applications.
Used in Organic Synthesis:
Quinoline, 2,4,8-trichloro-7-methoxy-, is used as a building block in the synthesis of other complex organic compounds due to its versatile reactivity, enabling the creation of novel compounds with diverse applications.

Check Digit Verification of cas no

The CAS Registry Mumber 893620-26-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,3,6,2 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 893620-26:
(8*8)+(7*9)+(6*3)+(5*6)+(4*2)+(3*0)+(2*2)+(1*6)=193
193 % 10 = 3
So 893620-26-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H6Cl3NO/c1-15-7-3-2-5-6(11)4-8(12)14-10(5)9(7)13/h2-4H,1H3

893620-26-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4,8-trichloro-7-methoxyquinoline

1.2 Other means of identification

Product number -
Other names 2,4,8-tris(chloranyl)-7-methoxy-quinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:893620-26-3 SDS

893620-26-3Relevant articles and documents

Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections

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Page/Page column 105; 106, (2016/06/28)

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, and pharmaceutical compositions and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease

Alexandre, Fran?ois-René,Brandt, Guillaume,Caillet, Catherine,Chaves, Dominique,Convard, Thierry,Derock, Michel,Gloux, Damien,Griffon, Yann,Lallos, Lisa,Leroy, Frédéric,Liuzzi, Michel,Loi, Anna-Giulia,Moulat, Laure,Musiu, Chiara,Parsy, Christophe,Rahali, Houcine,Roques, Virginie,Seifer, Maria,Standring, David,Surleraux, Dominique

, p. 3984 - 3991 (2015/08/24)

Abstract We disclose here the synthesis of a series of macrocyclic HCV protease inhibitors, where the homoserine linked together the quinoline P2′ motif and the macrocyclic moiety. These compounds exhibit potent inhibitory activity against HCV NS3/4A protease and replicon cell based assay. Their enzymatic and antiviral activities are modulated by substitutions on the quinoline P2′ at position 8 by methyl and halogens and by small heterocycles at position 2. The in vitro structure activity relationship (SAR) studies and in vivo pharmacokinetic (PK) evaluations of selected compounds are described herein.

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320

Parsy, Christophe C.,Alexandre, Fran?ois-René,Bidau, Valérie,Bonnaterre, Florence,Brandt, Guillaume,Caillet, Catherine,Cappelle, Sylvie,Chaves, Dominique,Convard, Thierry,Derock, Michel,Gloux, Damien,Griffon, Yann,Lallos, Lisa B.,Leroy, Frederic,Liuzzi, Michel,Loi, Anna-Giulia,Moulat, Laure,Chiara, Musiu,Rahali, Houcine,Roques, Virginie,Rosinovsky, Elodie,Savin, Simon,Seifer, Maria,Standring, David,Surleraux, Dominique

, p. 5427 - 5436 (2015/11/09)

Exploration of the P2 region by mimicking the proline motif found in BILN2061 resulted in the discovery of two series of potent HCV NS3/4A protease inhibitors. X-ray crystal structure of the ligand in contact with the NS3/4A protein and modulation of the

MACROCYCLIC SERINE PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE FOR TREATING HCV INFECTIONS

-

, (2012/08/28)

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, and pharmaceutical compositions and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV

-

Page/Page column 148-149, (2011/02/24)

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula (Ia) or (Ib), pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

MACROCYCLIC SERINE PROTEASE INHIBITORS

-

, (2010/11/03)

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

MACROCYCLIC SERINE PROTEASE INHIBITORS

-

, (2009/08/18)

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof

MACROCYCLIC SERINE PROTEASE INHIBITORS

-

Page/Page column 123, (2009/03/07)

Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.

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