113206-03-4

Basic information

• Product Name: 2-Chloro-3-methoxyaniline
• Synonyms: Benzenamine, 2-chloro-3-methoxy-;2-Chloro-3-methoxybenzenamine;(2-Chloro-3-methoxyphenyl)amine;2-Chloro-3-methoxyaniline;2-chloro-3-methoxyl-aniline;1,3-ADAMANTANEDIMETHANOL,ALPHA,ALPHA,ALPHA'',ALPHA''-TETRAMETHYL-(6CI);2-chloro-3-Methoxy-;3-AMino-2-chloroanisole[2-Chloro-3-Methoxyaniline]
• CAS NO: 113206-03-4
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• Product Categories: Drug Intermediates;API intermediates;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Naphthyridine,Quinoline
• Mol File: 113206-03-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 50 °C
• Boiling Point: 252 °C at 760 mmHg
• Flash Point: 106.2 °C
• Appearance: Kind of white to yellow powder
• Density: 1.234 g/cm³
• Vapor Pressure: 0.00191mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-methoxyaniline(113206-03-4)
• EPA Substance Registry System: 2-Chloro-3-methoxyaniline(113206-03-4)

Safety Data

• Hazardous Substances Data: 113206-03-4(Hazardous Substances Data)

Usage

Uses

2-Chloro-3-methoxyaniline is a reactant used in the preparation of dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.

InChI:InChI=1/C7H8ClNO.ClH/c1-10-6-4-2-3-5(9)7(6)8;/h2-4H,9H2,1H3;1H

Upstream product

• 16554-45-3 2-methoxy-6-nitroaniline 
• 1073118-74-7 C₁₂H₁₆ClNO₃ 
• 3970-39-6 2-chloro-3-methoxynitrobenzene 

Downstream Products

• 923289-36-5 1-(2-amino-3-chloro-4-methoxy-phenyl)ethanone 
• 56962-01-7 2-chloro-3-aminophenol 
• 1180496-46-1 4-(4-methoxybenzyloxy)-8-chloro-7-methoxy-2-(4-methylthiazol-2-yl)quinoline 
• 1108659-39-7 2,8-dichloro-7-methoxy-4-(4-methoxybenzyloxy)quinoline 
• 893620-26-3 2,4,8-trichloro-7-methoxyquinoline 
• 1269467-56-2 C₂₀H₁₄ClN₅OS 
• 1357171-41-5 C₂₁H₁₆ClN₃O₃ 
• 1253380-82-3 methyl [[(2-chloro-4-fluorophenyl)methyl](2-{[2-chloro-3-(methyloxy)phenyl]amino}ethyl)amino](oxo)acetate 
• 801281-96-9 C₁₃H₁₄ClNO₅ 

Relevant articles and documents

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TRPV4 ANTAGONISTS

The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

SAR analysis performed with a limited set of cyclopentane-containing macrocycles led to the identification of N-[17-[2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy]- 13-methyl-2,14-dioxo-3,13-diazatricyclo [13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamid e (TMC435350, 32c) as a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM). TMC435350 also displayed low in vitro clearance and high permeability, which were confirmed by in vivo pharmacokinetic studies. TMC435350 is currently being evaluated in the clinics.