893620-80-9

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 371-40-4 4-fluoroaniline 
• 109-12-6 2-aminopyrimidine 
• 395-25-5 bis(4-fluorophenyl)sulfoxide 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1447064-40-5 5-methoxy-2,3-diphenyl-1-(pyrimidin-2-yl)-1H-indole 
• 1447064-42-7 5-fluoro-2,3-diphenyl-1-(pyrimidin-2-yl)-1H-indole 
• 1447064-70-1 5-fluoro-1-(pyrimidin-2-yl)-2,3-di-p-tolyl-1H-indole 
• 1447064-74-5 5-fluoro-2,3-bis(4-methoxyphenyl)-1-(pyrimidin-2-yl)-1H-indole 
• 1470409-05-2 2-(4-fluoroanilino)-1,4,5,6-tetrahydropyrimidine 
• 364-78-3 2-nitro-4-fluoroaniline 
• 1369850-78-1 3-(tert-butyl)-4-fluoroaniline 

Relevant academic research and scientific papers

Palladium-Catalyzed Amination of Aryl Sulfides and Sulfoxides with Azaarylamines of Poor Nucleophilicity

The amination of aryl sulfides and sulfoxides with azaarylamines is investigated using a palladium-N-heterocyclic carbene (NHC) complex. Because azaarylamines are less nucleophilic than anilines, more reactive diaryl sulfides and sulfoxides are found to be suitable coupling partners that liberate better leaving arenethiolate or arenesulfenate anions, instead of aryl methyl sulfides as reported previously.

Multiple Roles of the Pyrimidyl Group in the Rhodium-Catalyzed Regioselective Synthesis and Functionalization of Indole-3-carboxylic Acid Esters

A regioselective synthesis of indole-3-carboxylic acid esters from anilines and diazo compounds has been realized by making use of the pyrimidyl group-assisted rhodium-catalyzed C-H activation and C-N bond formation. The reaction proceeds under mild conditions, exhibits good functional group tolerance and scalability. Reutilization of the pyrimidyl directing group in the resulting products provided an efficient strategy for further C-7 functionalization of indoles. Moreover, the pyrimidyl moiety could be readily removed as a leaving group to offer various free N-H indoles.

Synthesis of cyclic guanidines: 2-arylamino-1,4,5,6-tetrahydropyrimidines

Considering the biological and chemical relevance of guanidine containing derivatives, we have devised a novel and efficient two-step synthesis of 2-arylamino-1,4,5,6-tetrahydropyrimidines. We have found that the coupling of aryl bromides with 2-aminopyri

Zinc base assisted amination of 2-chloropyrimidines by aniline derivatives at room temperature

The amination of 2-chloropyrimidines was performed with several aniline derivatives in the presence of tolylzinc bromide as a base. The organozinc compound has a profound effect on the reactivity of the amines, so that the reaction takes place at room tem