89371-46-0

Upstream product

• 89371-88-0 benzyl (4S)-1-benzyl-3-benzyloxycarbonyl-2-oxo-imidazolidine-4-carboxylate 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 

Downstream Products

• 89371-47-1 benzyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 89384-27-0 benzyl (4S)-1-benzyl-3-{(2S)-[N-((1S)-1-ethoxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 89384-28-1 benzyl (4S)-1-benzyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 393548-62-4 (S)-1-Benzyl-3-((S)-2-tert-butoxycarbonylamino-3-methyl-butyryl)-2-oxo-imidazolidine-4-carboxylic acid benzyl ester 
• 393547-09-6 (3-{[(S)-3-((S)-2-Amino-3-methyl-butyryl)-1-benzyl-2-oxo-imidazolidine-4-carbonyl]-amino}-2-oxo-hexanoylamino)-acetic acid allyl ester 
• 811803-64-2 ((S)-1-{(S)-5-[1-(Allylcarbamoyl-hydroxy-methyl)-butylcarbamoyl]-3-benzyl-2-oxo-imidazolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester 
• 393547-01-8 (S)-3-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-methyl-butyryl]-1-benzyl-2-oxo-imidazolidine-4-carboxylic acid (1-allylaminooxalyl-butyl)-amide 
• 393547-07-4 (3-{[(S)-1-Benzyl-3-((S)-2-tert-butoxycarbonylamino-3-methyl-butyryl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-oxo-hexanoylamino)-acetic acid allyl ester 
• 393548-68-0 (3-{[(S)-1-Benzyl-3-((S)-2-tert-butoxycarbonylamino-3-methyl-butyryl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester 
• 811803-63-1 [(S)-1-((S)-1-{(S)-5-[1-(Allylcarbamoyl-hydroxy-methyl)-butylcarbamoyl]-3-benzyl-2-oxo-imidazolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester 
• 393546-99-1 ((S)-1-{(S)-1-[(S)-5-(1-Allylaminooxalyl-butylcarbamoyl)-3-benzyl-2-oxo-imidazolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-2-methyl-propyl)-carbamic acid tert-butyl ester 
• 393547-03-0 (S)-4-((S)-2-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-((S)-1-{(S)-1-[(S)-5-(1-allylaminooxalyl-butylcarbamoyl)-3-benzyl-2-oxo-imidazolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-2-methyl-propylcarbamoyl)-butyric acid tert-butyl ester 
• 393547-13-2 4-(2-acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-[1-(1-{5-[1-(allyloxycarbonylmethyl-aminooxalyl)-butylcarbamoyl]-3-benzyl-2-oxo-imidazolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-2-methyl-propylcarbamoyl]-butyric acid tert-butyl ester 
• 89371-52-8 (4S)-1-benzyl-3-<(2S)-2-amino>propionyl>-2-oxoimidazolidine-4-carboxylic acid 

Relevant academic research and scientific papers

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: Synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex

Synthesis and HCV NS3 serine protease inhibitory activity of some novel 2-oxoimidazolidine-4-carboxylic acid derivatives are reported. X-ray structure of an inhibitor, 15c bound to the protease is presented. Synthesis and HCV NS3 serine protease inhibitor

Studies on Angiotensin Converting Enzyme Inhibitors. 4. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of 3-Acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic Acid Derivatives

(4S)-1-Alkyl-3-acyl>-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods.Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed.The dicarboxylic acids 3a-n possessing S,S,S configuration showed potent in vitro ACE inhibitory activities with IC 50 values of 1.1x10-8-1.5x10-9 M.The most potent compound in this series, monoester 3p, had an ID 50 value of 0.24 mg/kg, po for inhibition of angiotensin I induced pressor response in normotensive rats and produced a dose-dependent decrease in systolic blood pressure of spontaneously hypertensive rats (SHRs) at doses of 1-10 mg/kg, po.

ANTIHYPERTENSIVE 2-OXO-IMIDAZOLIDINE DERIVATIVES

Novel 2-oxo-imidazolidine derivative of the formula: STR1 wherein R 1 is lower alkyl or phenyl-lower alkyl, R 2 is lower alkyl, R. sup.3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R 4 is hydrogen or lower alkyl, and a pharmaceutically acceptable salts thereof are disclsoed. Said compounds (I) and salts thereof are useful as hypotensive agents.