893775-86-5Relevant academic research and scientific papers
Heteropolyacid ionic liquid heterogeneously catalyzed synthesis of isochromansviaoxa-Pictet-Spengler cyclization in dimethyl carbonate
Yang, Guoping,Li, Ke,Zeng, Kai,Li, Yijin,Yu, Tao,Liu, Yufeng
, p. 10610 - 10614 (2021)
A recyclable and efficient heterogeneous, green catalyst based on the synthesis of Keggin-type polyoxometalate (H3PMo12O40) and vitamin B1 analogue 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium (HEMT),i.e., [HEMTH]H2[PMo12O40] was prepared. Oxa-Pictet-Spengler cyclization of arylethanols and aldehydes were catalyzed to afford various substituted isochromans in moderate conditions with excellent yields using dimethyl carbonate (DMC) as a green solvent. Furthermore, this protocol was applicable in a gram-scale reaction, and the catalyst could be recycled eight times without significant loss of activity.
Synthesis of isochromans via Fe(OTf)2-catalyzed Oxa-Pictet–Spengler cyclization
Zhou, Jimei,Wang, Chao,Xue, Dong,Tang, Weijun,Xiao, Jianliang,Li, Chaoqun
supporting information, p. 7040 - 7046 (2018/10/20)
Fe(OTf)2 has been found to be an efficient catalyst for the Oxa-Pictet–Spengler cyclization reaction leading to isochromans. A series of substituted isochromans were obtained with good to excellent isolated yields by coupling β-arylethanols wit
Oxa-Pictet-Spengler reaction in water. Synthesis of some (±)-1-aryl-6,7-dimethoxyisochromans
Saeed, Aamer
experimental part, p. 261 - 264 (2010/11/19)
An acid catalyzed oxa-Pictet-Spengler reaction 'on water' leading to the synthesis of a variety of 1-aryl-6,7-dimethoxyisochromans is described. The aqueous chemistry is a much cleaner, efficient, cheaper and simple method for synthesis. The scope of reac
Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists
Gitto, Rosaria,Zappala, Maria,De Sarro, Giovambattista,Chimirri, Alba
, p. 129 - 134 (2007/10/03)
2,3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA-type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodeg
