89379-40-8

Usage

Uses

Used in Pharmaceutical Industry:
1-DIMETHYLAMINO-2-METHYL-2-AMINOPROPANE is used as a reactant in the preparation and structure-activity relationships of angular benzophenazine dual topoisomerase I and topoisomerase II inhibitors as anticancer agents. This application takes advantage of its ability to contribute to the development of novel compounds with potential therapeutic effects against cancer by targeting essential cellular enzymes involved in DNA replication and transcription.

InChI:InChI=1/C6H16N2/c1-6(2,7)5-8(3)4/h5,7H2,1-4H3

Upstream product

• 91447-49-3 dimethyl-(β-nitro-isobutyl)-amine; hydrochloride 
• 62983-26-0 2-Amino-N',N'-dimethylisobutyramid 
• 19155-54-5 1-Dimethylamino-2-methyl-2-nitro-propan 

Downstream Products

• 175866-20-3 3-Cyclohexyl-5-ethoxy-1,3-dihydro-1-[2-methoxy-4-[N-(2-dimethylamino-1,1-dimethylethyl)carbamoyl]benzyl]-2H-benzimidazol-2-one 

Relevant academic research and scientific papers

2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

A compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

AMIDOPYRAZOLE DERIVATIVE

A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I): wherein Ar1 and Ar2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.

1-(2-Methyl-2-propenyl)-3-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde and 1-(2-methyl-2-propenyl)-4-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde

Described are the compounds 1-(2-methyl-2-propenyl)-3-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde and 1-(2-methyl-2-propenyl)-4-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde; and a process for preparing same by means of reacting a methallylic halide with a mixture of 3 and 4-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehyde using a phase transfer agent in a two phase system according to the reaction: STR1 wherein the carboxaldehyde moiety is bonded to the alpha-carbon atom or the beta-carbon atom, X is chloro or bromo and M is alkali metal, processes for adding such 1-(2-methyl-2-propenyl)-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehydes to consumable materials whereby: I. In foodstuffs and medicinal products, floral, muguet, coriander, fatty, green and creamy aroma and flavor characteristics are augmented or enhanced; Ii. In perfumes and perfumed articles, citrus, floral and fatty nuances are imparted, augmented and/or enhanced; and Iii. In tobaccos and tobacco flavor and aroma imparting or enhancing compositions, sweet, spicey, coriander-like, citrus/fruity notes are imparted, prior to, and, on smoking And tobacco, foodstuff, flavor and perfume compositions containing the 1-(2-methyl-2-propenyl)-(4-methyl-3-pentenyl)-Δ3 -cyclohexene-1-carboxaldehydes.