894-23-5

Upstream product

• 63203-48-5 1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 467443-10-3 1-[3-(4-methoxy-phenyl)-ureido]-cyclohexanecarboxylic acid ethyl ester 
• 18908-07-1 3-methoxyphenyl isocyanate 
• 586-38-9 3-Methoxybenzoic acid 
• 1711-05-3 m-anisoyl chloride 

Downstream Products

• 1044501-12-3 3-[4-(methyloxy)phenyl]-1,3-diazaspiro[4.5]decan-2-one 

Relevant academic research and scientific papers

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of Formula (I) or a salt thereof are provided: wherein R6, R7, R8, R21, X, Ar, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.

Synthesis, selective aldose reductase inhibitory profile and antihyperglycaemic potential of certain parabanic acid derivatives

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1 g, 1p, and 1o which showed inhibitory activity, 36.6, 90 and 91% respectively, at concentration 1 × 10-4. Their IC50 were 2 × 10-6, 7.5 × 10-8 and 5 × 10-8, respectively. Compound 1o exhibited pronounced antihyperglycaemic effect.