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LDN-212320 is a small molecule activator of glutamate transporter EAAT2 translation, which provides neuroprotection and shows potential for the therapeutic treatment of neurodegenerative diseases.

894002-50-7

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894002-50-7 Usage

Uses

Used in Pharmaceutical Industry:
LDN-212320 is used as a neuroprotective agent for its potential therapeutic treatment of neurodegenerative diseases. It enhances the function of glutamate transporter EAAT2, which helps protect neurons from damage and degeneration.

Check Digit Verification of cas no

The CAS Registry Mumber 894002-50-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,4,0,0 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 894002-50:
(8*8)+(7*9)+(6*4)+(5*0)+(4*0)+(3*2)+(2*5)+(1*0)=167
167 % 10 = 7
So 894002-50-7 is a valid CAS Registry Number.

894002-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name G-1

1.2 Other means of identification

Product number -
Other names G-1

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:894002-50-7 SDS

894002-50-7Downstream Products

894002-50-7Relevant academic research and scientific papers

Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

Xing, Xuechao,Chang, Ling-Chu,Kong, Qiongman,Colton, Craig K.,Lai, Liching,Glicksman, Marcie A.,Lin, Chien-Liang Glenn,Cuny, Gregory D.

, p. 5774 - 5777 (2011/10/18)

Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. A thiopyridazine derivative has been found to increase EAAT2 protein levels in astrocytes. A structure-activity relationship study revealed that several components of the molecule were required for activity, such as the thioether and pyridazine. Modification of the benzylthioether resulted in several derivatives (7-13, 7-15 and 7-17) that enhanced EAAT2 levels by >6-fold at concentrations 50 of 0.5 μM.

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