89407-98-7

Basic information

• Product Name: 4-(2-piperdinylethoxy)benzoic acid hydrochloride
• Synonyms: 4-(2-piperdinylethoxy)benzoic acid hydrochloride;Benzoic acid, 4-[2-(1-piperidinyl)ethoxy]-
• CAS NO: 89407-98-7
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 285.7665
• Mol File: 89407-98-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 413.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• PKA: 4.37±0.10(Predicted)
• CAS DataBase Reference: 4-(2-piperdinylethoxy)benzoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-piperdinylethoxy)benzoic acid hydrochloride(89407-98-7)
• EPA Substance Registry System: 4-(2-piperdinylethoxy)benzoic acid hydrochloride(89407-98-7)

Safety Data

• Hazardous Substances Data: 89407-98-7(Hazardous Substances Data)

Usage

General Description

4-(2-piperdinyethoxy)benzoic acid hydrochloride is a complex chemical compound that has various potential applications in chemical and pharmaceutical research due to its structure and properties. It is formed from the combination of 4-(2-piperdinylethoxy)benzoic acid with a hydrochloride molecule. Its exact chemical structure involves a piperidine ring - a six-membered organic compound that contains nitrogen - linked to a benzoic acid moiety via an ethoxy chain. The additional hydrochloride moiety enhances its solubility in water, making it easier to handle and apply in a wide range of situations. Like many chemicals in its class, it is generally stored in a cool, dry place to maintain its stability and prevent degradation. It bears potential use in the synthesis of a wide range of other chemicals or as a reagent in certain chemical reactions.

Upstream product

• 3040-44-6 1-piperidinoethanol 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 89407-97-6 4-[2-(N-piperidine)-ethoxy]benzoic acid methyl ester 
• 93148-78-8 ethyl 4-(2-Piperidinylethoxy)benzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Downstream Products

• 1319210-03-1 N-(2-acetylphenyl)-4-(2-piperidin-1-ylethoxy)benzamide 
• 1319210-09-7 2-[4-(2-piperidin-1-ylethoxy)phenyl]quinolin-4-ol 
• 1260244-32-3 N,N-diethyl-2-({2-[4-(2-piperidin-1-ylethoxy)phenyl]-quinolin-4-yl}oxy)ethanamine 
• 166975-76-4 4-(2-(piperidin-1-yl)ethoxy)benzoyl chloride 
• 1365645-69-7 C₂₇H₃₅BrN₆O₂ 
• 1365645-31-3 C₁₉H₂₀BrClN₄O 
• 96718-99-9 N-[2-(3-Methoxy-phenyl)-ethyl]-N-phenyl-4-(2-piperidin-1-yl-ethoxy)-benzamide 

Relevant articles and documents

A novel [...] compound of preparation and its use in cancer therapy (by machine translation)

The invention belongs to the field of biology, discloses a new naphthol compound of the design and its preparation method, and this compound or its biological acceptable salt as active ingredient preparation in cell growth control mechanism and application in cancer therapy. Through the biological activity tests show that, the invention relates to the compounds of tumor cells STAT3 cell signal transduction has obvious inhibition effect, and to lung cancer, breast cancer, colon cancer and leukemia such as the proliferation of the cancer cell is obviously antagonistic effect. This class of compounds for the treatment of cancer and cancer clinical potential mechanism to study the significance, with great potential for development, it has very good application prospect. (by machine translation)

Evolution from a natural flavones nucleus to obtain 2-(4-propoxyphenyl) quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump

Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of substrate antimicrobial agents. Inhibition of such pumps is a promising strategy to circumvent this resistance mechanism. NorA is a Staphylococcus aureus efflux pump that confers reduced susceptibility to many structurally unrelated agents, including fluoroquinolones, resulting in a multidrug resistant phenotype. In this work, a series of 2-phenyl-4(1H)- quinolone and 2-phenyl-4-hydroxyquinoline derivatives, obtained by modifying the flavone nucleus of known efflux pump inhibitors (EPIs), were synthesized in an effort to identify more potent S. aureus NorA EPIs. The 2-phenyl-4- hydroxyquinoline derivatives 28f and 29f display potent EPI activity against SA-1199B, a strain that overexpresses norA, in an ethidium bromide efflux inhibition assay. The same compounds, in combination with ciprofloxacin, were able to completely restore its antibacterial activity against both S. aureus SA-K2378 and SA-1199B, norA-overexpressing strains.

Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzothiophene Derivatives Leading to thien-3-yl>phenyl>methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with On...

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzothiophene derivatives was synthesized.These compounds were prepared by Friedel-Crafts aroylation of appropriate O-protected 2-arylbenzothiophene nuclei with basic side-chain-bearing benzoyl chlorides followed by removal of the protective groups to provide the desired compounds containing both hydroxyl and basic side-chain functionality.A particularly useful method for the cleavage of aryl methoxy ethers without removal of (dialkylamino)ethoxy side chain functionality elsewhere in the molecule was found to be AlCl3/EtSH.The benzothiophene derivatives were tested for their ability to inhibit the growth-stimulating action of estradiol on the immature rat uterus.Seemingly minor changes in the side-chain amine moiety were found to have profound effects on the ability of the compounds to antagonize estradiol.Analogues having basic side chains containing cyclic (pyrrolidine, piperidine, and hexamethyleneamine) moieties were found to have less intrinsic estrogenicity and to antagonize estradiol action more completely than their noncyclic counterparts.The most effective antiestrogen in the series, compound 44, thien-3-yl>phenyl>methanone, elicited a modest uterotropic activity that did not increase with increasing dose.In antagonism of estradiol, 44 exhibited a degree of inhibition surpassing that of tamoxifen at any dose tested.The new benzothiophene antiestrogen was also shown to have high affinity for rat uterine cycloplasmic estrogen receptor and to be an inhibitor of the growth of DMBA-induced rat mammary tumors.