89409-89-2

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE is used as a building block for the synthesis of various drugs and pharmaceutical products. Its potential biological activity and unique structure make it a valuable component in the development of new pharmaceuticals and drugs.
Used in Medicine Production:
ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE is used as an intermediate in the production of medicines. Its unique structure and properties contribute to the development of new pharmaceuticals and drugs.
Used in Agrochemical Production:
ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE is also used as an intermediate in the production of agrochemicals. Its potential biological activity and unique structure make it a valuable component in the development of new agrochemicals.

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 126747-14-6 4-cyanophenylboronic acid 
• 496922-59-9 N-benzyl-N-(1-octynyl)-p-toluenesulfonamide 
• 5798-75-4 Ethyl 4-bromobenzoate 

Relevant academic research and scientific papers

Palladium-Catalyzed Three-Component Coupling of Ynamides

A palladium-catalyzed regioselective three-component coupling of ynamides was developed. The reaction proceeded smoothly to furnish the desired products when carried out at 70 °C in acetonitrile/water with potassium carbonate in the presence of 2.5 mol percent Pd2(dba)3·CHCl3 without a ligand. Various iodides and boronic acids were used in this reaction, and a carbon-carbon bond was formed with satisfactory regioselectivity from the ynamides.

Structure-reactivity relationships in negishi cross-coupling reactions

Competition experiments have been performed to determine the relative reactivities of substituted bromobenzenes and of different arylzinc reagents in the [Pd(PPh3)4]-catalyzed Negishi cross-coupling reaction in THF at 25 °C. The crosscoupling reactions are accelerated by electron acceptors in the bromobenzenes, the effect of which increases in the order ortho a larger effect than substituent variations in the arylzinc halides (ρ = -0.98).

Efficient cobalt-catalyzed formation of unsymmetrical biaryl compounds and its application in the synthesis of a sartan intermediate

(Chemical Equation Presented) No prior preparation of the organometallic reagent is required in a cobalt-catalyzed coupling of two different aryl halides under mild conditions (see scheme). A broad spectrum of valuable biaryl compounds can be prepared in this way. Not only may a variety of reactive substituents be present, but heteroaryl halides and aryl triflates are also suitable substrates. DMF = N,N-dimethylformamide, FG = functional group.

Synthesis of unsymmetrical biaryls by electroreductive cobalt-catalyzed cross-coupling of aryl halides

The consumable anode process allows the electrochemical cross-coupling reaction between various functionalized aromatic halides (iodides, bromides and chlorides) in the presence of cobalt halides as catalyst in a mixed solvent acetonitrile/pyridine (9:1). A great variety of unsymmetrical biaryls are obtained in moderate to excellent yields.