89409-89-2

Basic information

• Product Name: ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE
• Synonyms: ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE;[1,1'-Biphenyl]-4-carboxylic acid, 4'-cyano-, ethyl ester;Ethyl 4-(4-cyanophenyl)benzoate;4'-Cyano-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
• CAS NO: 89409-89-2
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.28
• Mol File: 89409-89-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 123-124.5℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE(89409-89-2)
• EPA Substance Registry System: ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE(89409-89-2)

Safety Data

• Hazardous Substances Data: 89409-89-2(Hazardous Substances Data)

Usage

General Description

Ethyl 4'-cyanobiphenyl-4-carboxylate is a chemical compound commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical products. It is a derivative of biphenyl, with a cyanide group attached to the 4' position and an ethyl ester group attached to the carboxylate group at the 4 position. ETHYL 4'-CYANOBIPHENYL-4-CARBOXYLATE is known for its potential biological activity and is used as an intermediate in the production of medicines and agrochemicals. Its unique structure and properties make it a valuable component in the development of new pharmaceuticals and drugs.

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 623-00-7 4-bromobenzenecarbonitrile 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 126747-14-6 4-cyanophenylboronic acid 
• 496922-59-9 N-benzyl-N-(1-octynyl)-p-toluenesulfonamide 

Relevant articles and documents

Palladium-Catalyzed Three-Component Coupling of Ynamides

A palladium-catalyzed regioselective three-component coupling of ynamides was developed. The reaction proceeded smoothly to furnish the desired products when carried out at 70 °C in acetonitrile/water with potassium carbonate in the presence of 2.5 mol percent Pd2(dba)3·CHCl3 without a ligand. Various iodides and boronic acids were used in this reaction, and a carbon-carbon bond was formed with satisfactory regioselectivity from the ynamides.

Efficient cobalt-catalyzed formation of unsymmetrical biaryl compounds and its application in the synthesis of a sartan intermediate

(Chemical Equation Presented) No prior preparation of the organometallic reagent is required in a cobalt-catalyzed coupling of two different aryl halides under mild conditions (see scheme). A broad spectrum of valuable biaryl compounds can be prepared in this way. Not only may a variety of reactive substituents be present, but heteroaryl halides and aryl triflates are also suitable substrates. DMF = N,N-dimethylformamide, FG = functional group.