89433-06-7

Basic information

• Product Name: 2-(2-amino-5-methoxyphenyl)propan-2-ol
• Synonyms: 2-(2-amino-5-methoxyphenyl)propan-2-ol
• CAS NO: 89433-06-7
• Molecular Weight: 181.235
• Mol File: 89433-06-7.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-amino-5-methoxyphenyl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-amino-5-methoxyphenyl)propan-2-ol(89433-06-7)
• EPA Substance Registry System: 2-(2-amino-5-methoxyphenyl)propan-2-ol(89433-06-7)

Safety Data

• Hazardous Substances Data: 89433-06-7(Hazardous Substances Data)

Upstream product

• 2475-80-1 methyl 2-amino-5-methoxybenzoate 
• 74-88-4 methyl iodide 
• 75-16-1 methylmagnesium bromide 
• 23042-77-5 1-(2-amino-5-methoxy-phenyl)-ethanone 
• 917-54-4 methyllithium 

Downstream Products

• 128368-44-5 (2-Isopropenyl-4-methoxy-phenyl)-carbamic acid methyl ester 
• 128368-46-7 [(2-Isopropenyl-4-methoxy-phenyl)-methoxycarbonyl-amino]-acetic acid 
• 128368-45-6 [(2-Isopropenyl-4-methoxy-phenyl)-methoxycarbonyl-amino]-acetic acid methyl ester 
• 128368-43-4 2-isopropenyl-4-methoxyaniline 

Relevant articles and documents

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

With a resurgence in interest in covalent drugs, there is a need to identify new moieties capable of cysteine bond formation that are differentiated from commonly employed systems such as acrylamide. Herein, we report on the discovery of new alkynyl benzoxazine and dihydroquinazoline moieties capable of covalent reaction with cysteine. Their utility as alternative electrophilic warheads for chemical biological probes and drug molecules is demonstrated through site-selective protein modification and incorporation into kinase drug scaffolds. A potent covalent inhibitor of JAK3 kinase was identified with superior selectivity across the kinome and improvements in in vitro pharmacokinetic profile relative to the related acrylamide-based inhibitor. In addition, the use of a novel heterocycle as a cysteine reactive warhead is employed to target Cys788 in c-KIT, where acrylamide has previously failed to form covalent interactions. These new reactive and selective heterocyclic warheads supplement the current repertoire for cysteine covalent modification while avoiding some of the limitations generally associated with established moieties.

AROMATIC SULFONE COMPOUND AS ALDOSTERONE RECEPTOR MODULATOR

The present invention provides a compound represented by the following formula (I): [wherein, A represents a group of the following formula (A-1): etc., R1 and R2 each independently represent a hydrogen atom etc., Z represents CR3 etc., W represents CR4 etc., Q represents CR5 etc., R3, R4 and R5 each independently represent a hydrogen atom etc., Y represents an oxygen atom or sulfur atom, X represents an oxygen atom etc. and B represents an optionally substituted aryl group or optionally substituted heteroaryl group], the prodrug thereof or the pharmaceutically acceptable salt thereof for preventing or treating various diseases such as hypertesion, cerebral stroke, cardiac failure, etc.

Novel and facile route to (+)-physovenine via intramolecular [2+2]cycloaddition reaction

A formal total synthesis of (±)-physovenine 1 from 2-amino-5-methoxyacetophenone 2 via an intramolecular [2+2]cycloaddition reaction is described.

Substituted benzoxazin-2-ones and pharmaceutical compositions containing them

This invention is directed to novel benzoxazin-2-ones of the formula STR1 wherein A is a sulfur atom or an SO, SO2, R--N=S, or R--N=SO2 group where R is a hydrogen atom or an acyl group; D is an alkylene group; R1 is an al