89435-66-5Relevant academic research and scientific papers
SHORT CHAIN PEPTIDE INHIBITORS OF HUMAN RENIN
Matsueda, Rei,Yabe, Yuichiro,Kogen, Hiroshi,Higashida, Susumu,Koike, Hiroyuki,et al.
, p. 1041 - 1044 (2007/10/02)
The phenylalanine residue in the C-terminal sequence of angiotensin II was found to be important for the design of renin inhibitors. 1-Naphthylalanine(Nal(1))-containing tripeptide analogues such as benzyloxycarbonyl-Na1(1)-His-Leucinal (ES-188) and benzyloxycarbonyl-Nal(1)-His-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (Statine)5 2(S)-methylbuthylamide (ES-254) showed high potency and specificity to human renin.
HYPOTENSIVE PEPTIDES AND THEIR USE
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, (2008/06/13)
Oligopeptides of formula (I) STR1 (wherein R 1 CO--is an acyl group. But is an isobutyl or sec-butyl group and X is a variety of organic groups) and salts and esters thereof have valuable renin inhibitory activity.
