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Z-Nal(1)-His-Leucinal semicarbazone is a synthetic chemical compound with potential applications in pharmaceutical research. It is a derivative of leucine, an essential amino acid, and is characterized by the presence of a semicarbazone group. Z-Nal(1)-His-Leucinal semicarbazone is often used as a building block in the synthesis of more complex molecules, particularly in the development of drugs targeting the opioid receptor system. The "Z" in its name refers to the presence of a benzyloxycarbonyl (Z) protecting group, which is commonly used in peptide chemistry to prevent unwanted side reactions. The compound's structure and properties make it a valuable tool in medicinal chemistry for exploring the structure-activity relationships of opioid peptides and developing new therapeutic agents.

96386-80-0

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96386-80-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 96386-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,3,8 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 96386-80:
(7*9)+(6*6)+(5*3)+(4*8)+(3*6)+(2*8)+(1*0)=180
180 % 10 = 0
So 96386-80-0 is a valid CAS Registry Number.

96386-80-0Downstream Products

96386-80-0Relevant academic research and scientific papers

SHORT CHAIN PEPTIDE INHIBITORS OF HUMAN RENIN

Matsueda, Rei,Yabe, Yuichiro,Kogen, Hiroshi,Higashida, Susumu,Koike, Hiroyuki,et al.

, p. 1041 - 1044 (2007/10/02)

The phenylalanine residue in the C-terminal sequence of angiotensin II was found to be important for the design of renin inhibitors. 1-Naphthylalanine(Nal(1))-containing tripeptide analogues such as benzyloxycarbonyl-Na1(1)-His-Leucinal (ES-188) and benzyloxycarbonyl-Nal(1)-His-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (Statine)5 2(S)-methylbuthylamide (ES-254) showed high potency and specificity to human renin.

HYPOTENSIVE PEPTIDES AND THEIR USE

-

, (2008/06/13)

Oligopeptides of formula (I) STR1 (wherein R 1 CO--is an acyl group. But is an isobutyl or sec-butyl group and X is a variety of organic groups) and salts and esters thereof have valuable renin inhibitory activity.

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