89439-07-6Relevant academic research and scientific papers
Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells
Imagawa, Hiroshi,Saijo, Hayato,Yamaguchi, Hitomi,Maekawa, Ken,Kurisaki, Takahiro,Yamamoto, Hirofumi,Nishizawa, Mugio,Oda, Masataka,Kabura, Michiko,Nagahama, Masahiro,Sakurai, Jun,Kubo, Miwa,Nakai, Megumi,Makino, Kosho,Ogata, Mitsuko,Takahashi, Hironobu,Fukuyama, Yoshiyasu
, p. 2089 - 2093 (2012/04/17)
The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences.
Stereoselective synthesis of core structure of cortistatin A
Kotoku, Naoyuki,Sumii, Yuji,Kobayashi, Motomasa
supporting information; experimental part, p. 3514 - 3517 (2011/09/15)
A stereoselective synthesis of the core structure of cortistatin A (1), a novel antiangiogenic steroidal alkaloid from Indonesian marine sponge, is described. An 8-oxabicyclo[3.2.1]octene system, a characteristic B-ring structure of 1, was elaborated by a 7-endo selective intramolecular Heck cyclization and a subsequent acid-mediated oxy-Michael reaction.
A concise and convergent (formal) total synthesis of huperzine A
Lucey, Cathal,Kelly, Sean A.,Mann, John
, p. 301 - 306 (2008/03/27)
The first convergent synthesis of the tricyclic skeleton of huperzine A is described and includes, as the key step, an efficient regioselective intramolecular Heck reaction of 2-(tert-butyldimethylsilyloxymethyl)-6-(2- methoxy-5-bromopyridin-6-yl)methylcy
Azedaralide: total synthesis, relative and absolute stereochemical assignment
Baker, Luke A.,Williams, Craig M.,Bernhardt, Paul V.,Yanik, Gary W.
, p. 7355 - 7360 (2007/10/03)
Azedaralide, a potentially advanced intermediate for the total synthesis of various tetranortriterpenes, was constructed utilising the Fernández-Mateos protocol and assigned both relative and absolute stereochemistries. Both asymmetric aldol and classical
