894430-60-5

Upstream product

• 894430-43-4 (1S,3R,4S,7R)-7-benzyloxy-1-methanesulfonoxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 894430-48-9 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-5-(9'-fluorenylmethoxycarbonyl)-7-hydroxy-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-62-7 1-[(1S,3R,4S,7R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-5-(2,2,2-trifluoro-acetyl)-2-oxa-5-aza-bicyclo[2.2.1]hept-3-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 894430-46-7 (1S,3R,4S,7R)-7-benzyloxy-1-(4,4'-dimethoxytrityloxymethyl)-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 866611-96-3 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-44-5 (1S,3R,4S,7R)-7-benzyloxy-1-hydroxymethyl-3-(thymin-1-yl)-5-trifluoroacetyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-45-6 (1S,3R,4S,7R)-7-benzyloxy-1-hydroxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-61-6 Acetic acid (1S,3R,4S,7R)-7-benzyloxy-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-(2,2,2-trifluoro-acetyl)-2-oxa-5-aza-bicyclo[2.2.1]hept-1-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and hybridization studies of 2′-amino-α-L-LNA and tetracyclic "locked LNA"

A convergent route to a new class of locked nucleic acids, i.e., 2′-amino-α-L-LNA, has been developed. The optimized synthetic route to the corresponding phosphoramidite building block of thymine proceeds in 4% overall yield over 15 steps from the startin