89450-91-9Relevant academic research and scientific papers
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies
Liu, Mei,Wang, Sanyi,Clampit, Jill E.,Gum, Rebecca J.,Haasch, Deanna L.,Rondinone, Cristina M.,Trevillyan, James M.,Abad-Zapatero, Cele,Fry, Elizabeth H.,Sham, Hing L.,Liu, Gang
, p. 668 - 672 (2007/10/03)
A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity
