89451-56-9Relevant academic research and scientific papers
FIRST ASYMMETRIC SYNTHESIS OF 4-PIPERIDONES. PREPARATION OF OPTICALLY ACTIVE DIASTEREOMERS OF 1-α-PHENYLETHYL-2-METHYL-4-PIPERIDONE
Grishina, G. V.,Potapov, V. M.,Gudasheva, T. A.,Abdulganeeva, S. A.
, p. 1132 - 1136 (2007/10/02)
The fundamental possibility of carrying out the asymmetric synthesis of 4-piperidones on the basis of the transamination of 1-substituted 2-methyl-4-piperidone methiodides by optically active α-phenylethylamine was demonstrated; the optical yield of the asymmetric transamination is 50percent.The occurrence of asymmetric synthesis was confirmed by the isolation of enantiomers of 2-methyl-4-piperidol by reduction of the individual diastereomers of 1-α-phenyl-ethyl-2-methyl-4-piperidone to the corresponding 4-piperidols with subsequent removal of the chiral substituent attached to the nitrogen atom.
