89451-88-7Relevant academic research and scientific papers
A new facile method for the stereoselective synthesis of trans-2-aryl-3,3-dimethylcyclopropane-1-carboxylic acids
Chen, Bang-Chi,Ngu, Khehyong,Guo, Peng,Liu, Wen,Sundeen, Joseph E,Weinstein, David S,Atwal, Karnail S,Ahmad, Saleem
, p. 6227 - 6229 (2007/10/03)
A new facile method for the preparation of trans-2-aryl-3,3-dimethylcyclopropane-1-carboxylic acids was developed. The new method involved [2+2]-cycloaddition of styrenes with N,N,2-trimethylpropionamide followed by bromination and rearrangement of the resulting 3-aryl-2,2-dimethylcyclobutanones, affording the title compounds in two steps in 60-84% overall yields.
Intermediates in the preparation of 2,2-dimethyl-3-aryl-cyclopropanecarboxylic acids and esters
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, (2008/06/13)
A process for the preparation of 2,2-dimethyl-3-arylcyclopropanecarboxylic acid or ester of the formula STR1 in which Ar is naphthyl or the radical STR2 R1 is H or C1 -C4 -alkyl, Z is oxygen, sulphur, or 1,2-ethenediyl, an
