89473-44-9

Upstream product

• 80324-51-2 3′,4′,5,5′,7,8-hexahydroxyflavone hexamethyl ether 
• 856815-41-3 1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-1,3-propanedione 
• 121795-61-7 2'-(3,4,5-trimethoxybenzoyloxy)-3',4',6'-trimethoxyacetophenone 
• 89456-13-3 2,3-bis(benzyloxy)-4,6-dimethoxyacetophenone 
• 89456-40-6 8-Hydroxy-5,7-dimethoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 89456-27-9 3,4,5-Trimethoxy-benzoic acid 2-acetyl-6-benzyloxy-3,5-dimethoxy-phenyl ester 
• 89456-20-2 1-(3-Benzyloxy-2-hydroxy-4,6-dimethoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propane-1,3-dione 
• 89456-34-8 8-Benzyloxy-5,7-dimethoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 54299-57-9 3-benzyloxy-2-hydroxy-4,6-dimethoxyacetophenone 
• 21919-66-4 2,30dihydroxy-4,6-dimethoxyacetophenone 

Downstream Products

• 89473-38-1 5,7,8,3',4',5'-hexahydroxyflavone hexaacetate 
• 64251-87-2 5-hydroxy-7,8,3',4',5'-pentamethoxyflavone 

Relevant academic research and scientific papers

Substituted benzopyranones as telomerase inhibitors

The present invention relates to benzopyranone derivatives, to methods for treating telomerase-modulated diseases, in particular cancers, with said derivatives, to a process for their preparation, to their use as medicaments and to pharmaceutical compositions comprising them.

Two New Flavone Glycosides From The Leaves of Argyreia speciosa (Convolvulaceae)

We report the isolation and characterization of two new flavone glycosides, 7,8,3',4',5'-pentahydroxyflavone 5-O-α-L-rhamnopyranoside (1) and 7,8,3',4',5'-pentahydroxyflavone 5-O-β-D-glucopyranoside (2), from the leaves of Argyreia speciosa.

Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. VI. Demethylation of 8-Hydroxy-5,7-dimethoxyflavones with Anhydrous Aluminum Chloride or Bromide in Acetonitrile

The demethylation of seven 8-hydroxy-5,7-dimethoxyflavones with anhydrous aluminum chloride or bromide in acetonitrile was studied and the following results were obtained. (1) Anhydrous aluminum chloride in acetonitrile selectively split the 5-methoxyl group without cleavage of the 7-methoxyl group, and seven 5,8-dihydroxy-7-methoxy-flavones were quantitatively synthesized by the demethylation. (2) In the demethylation with anhydrous aluminum bromide, the 5- and 7-methoxyl groups on 4',5,7-trimethoxy- and 3',4',5,7-tetramethoxy-8-hydroxyflavone were selectively split to give the corresponding 5,7,8-trihydroxyflavones in good yield.However, the demethylation was not accessible to the synthesis of 5,7,8-trihydroxy-3',4',5'-trimethoxyflavone, 4',5,7,8-tetrahydroxy-3'-methoxy-, and 3',5,7,8-tetrahydroxy-4'-methoxyflavone, because of the cleavage of the methoxyl groups on the B ring.The synthesized flavones were employed for the identification of the two natural flavones, which were proposed to be 4',5,8-trihydroxy-7-methoxyflavone and 4',5,8-trihydroxy-3',7-dimethoxyflavone.The former, salvitin, was revised to 4',5,7-trihydroxy-6-methoxyflavone and the latter seemed to be 4',5,7-trihydroxy-3',8-dimethoxyflavone.