894776-31-9Relevant academic research and scientific papers
CRYSTAL AND SALT OF 1-CYCLOPROPYLMETHYL-4-Y2-(3,3,5,5)-TETRAMETHYLCYCLOHEXYL)PHENYL¨PIPERAZINE
-
, (2008/06/13)
Salts and crystals of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine have excellent cell adhesion inhibitory action and cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflam
CRYSTAL AND SALT OF 1-CYCLOPROPYLMETHYL-4-[2-(3,3,5,5)-TETRAMETHYLCYCLOHEXYL)PHENYL]PIPERAZINE
-
Page/Page column 31-32, (2008/06/13)
A crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexyl)phenyl]piperazine have excellent cellular adhesion inhibiting potency and cellular infiltration inhibiting potency. Therefore, these crystal and salt are useful as a preventive
INTERMEDIATE IN PRODUCTION OF [2-(3,3,5,5-TETRAMETHYLCYCLOHEXYL)PHENYL]PIPERAZINE COMPOUND
-
Page/Page column 27-28, (2008/06/13)
A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. [Chemical formulae] wherein R1 and R2 independently represent a hydrogen atom or an amino-protecting group for an amino group, or R1 and R2 may together form a pyrrole ring which may have a substituent.
