894797-89-8Relevant articles and documents
A synthesis of (aR,7S)-(-)-N-acetylcolchinol and its conjugate with a cyclic RGD peptide
Besong, Gilbert,Billen, Denis,Dager, Indu,Kocienski, Philip,Sliwinski, Eric,Tai, Lik Ren,Boyle, F. Thomas
, p. 4700 - 4710 (2008/09/21)
An asymmetric synthesis of (-)-N-acetylcolchinol is described based on a Suzuki-Miyaura coupling to generate the biaryl pharmacophore. The sole asymmetric centre was introduced by an asymmetric reduction of a dibenzosuberone derivative 24 using lithium bo