894797-89-8

Upstream product

• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 121-71-1 3-Hydroxyacetophenone 
• 100-44-7 benzyl chloride 
• 105805-16-1 1-[2-bromo-5-(phenylmethoxy)phenyl]ethanone 
• 73252-53-6 3,4,5-trimethoxy-2-iodobenzaldehyde 
• 894797-86-5 1-(4'-benzyloxy-6''-[1''',3''']-dioxolan-2'''-yl-2'',3'',4''-trimethoxybiphenyl-2'-yl)-ethanone 
• 1035933-58-4 6-formyl-2,3,4-trimethoxyphenylboronic acid 
• 69138-97-2 2-iodo-3,4,5-trimethoxybenzaldehyde cyclohexylimine 
• 73252-56-9 (2-bromo-3,4,5-trimethoxy-benzylidene)-cyclohexylamine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 35274-53-4 2-bromo-3,4,5-tri-methoxybenzaldehyde 
• 894797-93-4 2-(5-benzyloxy-2-bromo-phenyl)-2-methyl-[1,3]oxathiolane 
• 894762-72-2 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne 

Downstream Products

• 894762-73-3 3-benzyloxy-9,10,11-trimethoxy-dibenzo[a,c]cyclohepten-5-one 

Relevant academic research and scientific papers

A synthesis of (aR,7S)-(-)-N-acetylcolchinol and its conjugate with a cyclic RGD peptide

An asymmetric synthesis of (-)-N-acetylcolchinol is described based on a Suzuki-Miyaura coupling to generate the biaryl pharmacophore. The sole asymmetric centre was introduced by an asymmetric reduction of a dibenzosuberone derivative 24 using lithium bo

Asymmetric synthesis of (S)-(-)-N-acetylcolchinol via Ullmann biaryl coupling

A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of (S)-(-)-N-acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy. Asymmetric induction is achieved by enamide hydrogenation using FerroTANE catalysts.