73252-56-9Relevant academic research and scientific papers
Asymmetric synthesis of (S)-(-)-N-acetylcolchinol via Ullmann biaryl coupling
Broady, Simon D.,Golden, Michael D.,Leonard, John,Muir, James C.,Maudet, Mickael
, p. 4627 - 4630 (2008/02/06)
A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of (S)-(-)-N-acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy. Asymmetric induction is achieved by enamide hydrogenation using FerroTANE catalysts.
