89480-40-0

Upstream product

• 79974-68-8 N⁶-benzoyl-2',3'-bis-O-<(1,1-dimethylethyl)dimethylsilyl>adenosine 
• 75082-92-7 Triaethylammonium-6-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)adenosin-3'-(2-chlorphenyl)phosphat> 
• 2338-12-7 5-nitrobenzotriazole 
• 69504-09-2 N⁶-Benzoyl-2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine 
• 15074-54-1 2-chlorophenyl dichlorophosphate 

Relevant academic research and scientific papers

Formation of Interribonucleoside Phosphate Bond by the Use of Reagent Formed by the Reaction of 2-Chlorophenyl Phosphorodichloridate with 5-Nitrobenzotriazole and Preparation of Anticodon Triplet of Yeast tRNALys

The reagent formed by the reaction of 2-chlorophenyl phosphorodichloridate with an equimolar amount of 5-nitrobenzotriazole was treated with protected ribonucleosides having free 3'-OH, followed by protected ribonucleosides having free 5'-OH in pyridine for 8 h (the second step), the corresponding dinucleoside phosphates being obtained in 55-84 percent yields.When the second step was carried out in the presence of 2,6-lutidine, the yields were increased to 80-90 percent within 2 h.By this procedure, the anticodon triplet of yeast tRNALys was prepared in 71 percent yield.

Nucleotides, XVII. Synthesis of Homogeneous Adenosyl-3',5'-oligomers by the Phosphotriester Method

The chemical synthesis of the fully protected trimer 12, the tetramers 11 and 23 as well as the pentamer 14 was achieved in preparative scales starting from the fully blocked adenosine-3'-phosphotriesters 1, 2, and N6-benzoyl-2',3'-bis-O-(tert-