894802-88-1

Basic information

• Product Name: 3-OXO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID ETHYL ESTER
• Synonyms: 3-OXO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID ETHYL ESTER;BETA-OXO-3-(TRIFLUOROMETHYL)-BENZENEBUTANOIC ACID ETHYL ESTER;Ethyl 3-oxo-4-(3-trifluoroMethylphenyl)butanoate
• CAS NO: 894802-88-1
• Molecular Formula: C₁₃H₁₃F₃O₃
• Molecular Weight: 274.24
• Mol File: 894802-88-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-OXO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID ETHYL ESTER(894802-88-1)
• EPA Substance Registry System: 3-OXO-4-(3-TRIFLUOROMETHYL-PHENYL)-BUTYRIC ACID ETHYL ESTER(894802-88-1)

Safety Data

• Hazardous Substances Data: 894802-88-1(Hazardous Substances Data)

Usage

General Description

3-oxo-4-(3-trifluoromethyl-phenyl)-butyric acid ethyl ester, also known as Ethyl 3-oxo-4-(3-trifluoromethylphenyl)butanoate, is a chemical compound with the molecular formula C13H13F3O3. 3-oxo-4-(3-trifluoromethyl-phenyl)-butyric acid ethyl ester is commonly used in the synthesis and production of pharmaceuticals and agrochemicals due to its potential biological activities. It is a colorless liquid with a fruity odor and is soluble in organic solvents. It is known to have anti-inflammatory, analgesic, and antipyretic properties and is used in the development of various medications. The compound is also used in the field of chemistry as a building block for creating new molecules and as a research tool in chemical studies.

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Downstream Products

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Relevant articles and documents

Modulation of luminescence intensity of lanthanide complexes by photoinduced electron transfer and its application to a long-lived protease probe

Luminescent lanthanide complexes (Tb3+, Eu3+, etc.) have excellent properties for biological applications, including extraordinarily long lifetimes and large Stokes shifts. However, there have been few reports of lanthanide-based functional probes, because of the difficulty in designing suitable complexes with a luminescent on/off switch. Here, we have synthesized a series of complexes which consist of three moieties: a lanthanide chelate, an antenna, and a luminescence off/on switch. The antenna is an aromatic ring which absorbs light and transmits its energy to the metal, and the switch is a benzene derivative with a different HOMO level. If the HOMO level is higher than a certain threshold, the complex emits no luminescence at all, which indicates that the lanthanide luminescence can be modulated by photoinduced electron transfer (PeT) from the switch to the sensitizer. This approach to control lanthanide luminescence makes possible the rational design of functional lanthanide complexes, in which the luminescence property is altered by a biological reaction. To exemplify the utility of our approach to the design of lanthanide complexes with a switch, we have developed a novel protease probe, which undergoes a significant change in luminescence intensity upon enzymatic cleavage of the substrate peptide. This probe, combined with time-resolved measurements, was confirmed in model experiments to be useful for the screening of inhibitors, as well as for clinical diagnosis.